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Generic Aciphex Rabeprazole sodium 20mg

The trials included 316 subjects with daytime and nighttime heartburn who did not have esophageal erosions. Subjects received either Aciphex 10 mg, Aciphex 20 mg or placebo, and they were given a diary to keep track of their GERD symptoms. Subjects returned for assessment at week two and four. Trials results demonstrated that the percentage of heartburn-free daytime and/or nighttime periods was significantly greater with Aciphex 20 mg than with placebo. It is not certain if Aciphex passes into breast milk. Continue use of Aciphex and inform your doctor if you observe minor side effects like: Headache , Upset stomach or diarrhea , Insomnia or nervousness , Rash or itching . The recommended adult oral dose is one Aciphex 20 mg delayed-release tablet to be taken once daily after the morning meal for a period up to four weeks.

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Aciphex Drug Interactions

Rabeprazole works by blocking acid production in the stomach. This medication is known as a proton pump inhibitor (PPI). It is used to treat acid-related stomach/intestinal and throat (esophagus) problems (e.g., acid reflux or GERD, ulcers, erosive esophagitis, Zollinger-Ellison syndrome). Decreasing excess stomach acid can help relieve symptoms such as heartburn, difficulty swallowing, persistent cough, and trouble sleeping. It can also prevent serious acid damage to your digestive system (e.g., ulcers, cancer of the esophagus). The dosage and length of treatment is based on your medical condition and response to therapy.

Warnings

Take this medication by mouth usually once daily, with or without food, or as directed by your doctor. Do not crush, chew, or split this medication. Swallow the medication whole. If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. If you miss a dose, use it as soon as you remember. Do not share this medication with others. The highest tested dose produced a systemic exposure to rabeprazole (AUC) of 1.40 mg hr/mL which is 1.6 times the human exposure (plasma AUC 0-(infinity) = 0.88 mg hr/mL) at the recommended dose for GERD (20 mg/day).

Precautions

Worldwide, over 2900 patients have been treated with rabeprazole in Phase II-III clinical trials involving various dosages and durations of treatment. The maximum reported overdose was 80 mg. There were no clinical signs or symptoms associated with any reported overdose. Patients with Zollinger-Ellison syndrome have been treated with up to 120 mg rabeprazole QD. No specific antidote for rabeprazole is known. Rabeprazole is extensively protein bound and is not readily dialyzable.

Overdosage

There has been no experience with large overdoses with rabeprazole. Seven reports of accidental overdosage with rabeprazole have been received. In the event of overdosage, treatment should be symptomatic and supportive. Single oral doses of rabeprazole at 786 mg/kg and 1024 mg/kg were lethal to mice and rats, respectively. Because strategies for the management of overdose are continually evolving, it is advisable to contact a Poison Control Center to determine the latest recommendations for the management of an overdose of any drug. The single oral dose of 2000 mg/kg was not lethal to dogs.