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Do not take albendazole if you are pregnant. Avoid pregnancy for at least 1 month following albendazole therapy. Do not take albendazole without first talking to your doctor if you are breast-feeding a baby. Therefore, in the case of a long term treatment with this drug, a doctor should carefully monitorise the patient's response to the treatment (liver function tests, blood counts monitoring, etc), at least twice a month. The treatment with this drug (Albenza) can be continued only if the blood changes in the patient's body are modest. You must consult with your personal physician before you start taking this drug, because some rare fatalities are associated with a treatment with Albenza.
Albenza PrecautionsPatients should be advised that: Some people, particularly young children, may experience difficulties swallowing the tablets whole. In young children, the tablets should be crushed or chewed and swallowed with a drink of water. Albendazole may cause fetal harm, therefore, women of childbearing age should begin treatment after a negative pregnancy test. Albendazole has been shown to cause occasional (less than 1% of treated patients) reversible reductions in total white blood cell count. Rarely, more significant reductions may be encountered including granulocytopenia, agranulocytosis, or pancytopenia. Blood counts should be performed at the start of each 28-day treatment cycle and every 2 weeks during each 28-day cycle in all patients. Albendazole Adverse ReactionsBecause they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. Mean T max and mean plasma elimination half-life of albendazole sulfoxide were unchanged. One overdosage has been reported with Albenza in a patient who took at least 16 grams over 12 hours. The adverse event profile of albendazole differs between hydatid disease and neurocysticercosis. In addition to adverse events reported from clinical trials, the following events have been identified during world-wide post-approval use of Albenza. In the fed state, praziquantel (40 mg/kg) increased mean maximum plasma concentration and area under the curve of albendazole sulfoxide by about 50% in healthy subjects (n = 10) compared with a separate group of subjects (n = 6) given albendazole alone. Postmarketing Adverse ReactionsNo untoward effects were reported. Significant toxicity and mortality were shown in male and female mice at doses exceeding 5,000 mg/kg; in rats, at estimated doses between 1,300 and 2,400 mg/kg; in hamsters, at doses exceeding 10,000 mg/kg; and in rabbits, at estimated doses between 500 and 1,250 mg/kg. Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n = 7) compared with albendazole (20 mg/kg/day) alone (n = 12). |
