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Generic Anafranil Clomipramine 25/50mg

Always take it exactly as prescribed. This medicine may cause dry mouth. Hard candy, chewing gum, or bits of ice may relieve this problem. --If you miss a dose... If you take 1 dose at bedtime, consult your doctor. Do not take the missed dose in the morning. Ask your doctor to calculate the dose of Anafranil that suits you best. Anyone considering the use of Anafranil or any other antidepressant in a child or adolescent must balance this risk with the clinical need.

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Possible Food And Drug Interactions When Taking Anafranil

If Anafranil is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Anafranil should not be used during pregnancy unless absolutely necessary; some babies born to women who took Anafranil have had withdrawal symptoms such as jitteriness, tremors, and seizures. Anafranil appears in breast milk. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). An overdose of Anafranil can be fatal. If you suspect an overdose, seek medical attention immediately. Withdrawal symptoms, including jitteriness, tremor, and seizures, have been reported in neonates whose mothers had taken Anafranil until delivery.

Precautions

There are no adequate or well-controlled studies in pregnant women. Safety and effectiveness in the pediatric population other than pediatric patients with OCD have not been established Anyone considering the use of Anafranil in a child or adolescent must balance the potential risks with the clinical need. In a controlled clinical trial in children and adolescents (10 to 17 years of age), 46 outpatients received Anafranil for up to 8 weeks. In addition, 150 adolescent patients have received Anafranil in open-label protocols for periods of several months to several years.

Anafranil Adverse Reactions

Of the 196 adolescents studied, 50 were 13 years of age or less and 146 were 14 to 17 years of age. The adverse reaction profile in this age group is similar to that observed in adults. The risks, if any, that may be associated with Anafranil's extended use in children and adolescents with OCD have not been systematically assessed. The following table enumerates adverse events that occurred at an incidence of 1% or greater among patients with OCD who received Anafranil in adult or pediatric placebo-controlled clinical trials.

Overdosage

The second death involved a patient suspected of ingesting a dose of 5750 mg. The 10 nonfatal cases involved doses of up to 5000 mg, accompanied by plasma levels of up to 1010 ng/mL. All 10 patients completely recovered. Critical manifestations of overdose include cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic toxicity. Other CNS manifestations may include drowsiness, stupor, ataxia, restlessness, agitation, delirium, severe perspiration, hyperactive reflexes, muscle rigidity, and athetoid and choreiform movements.