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Generic Betapace Sotalol 40mg

Betapace is used to treat irregular heartbeat patterns but not all patients having this kind of disease is advised to use this drug. Betapace AF can cause serious ventricular arrhythmias, primarily torsade de pointes (TdP). Patients taking this drug should be monitored carefully with electrocardiogram. In taking Betapace, you must follow the direction or instructions exactly as the doctor told you to do. In case you did not understand the instruction, do not hesitate to tell your doctor pharmacist or nurse and ask them to clarify it to you. The serious side effects of Betapace include an allergic reaction such as difficulty breathing, closing of the throat, swelling of the lips, or hives; wheezing or shortness of breath; dizziness or fainting; slow or fast heartbeat; swelling of the feet and lower legs; chest or heart pain; severe diarrhea; unusual sweating; vomiting; have a less appetite compared to normal; becomes more thirsty than normal; blue or cold feet and hands; and rash.

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Betapace Intake Guidelines

Betapace AF (sotalol hydrochloride) has both beta-andrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. Betapace AF (sotalol hydrochloride) is a racemic mixture of d- and l-sotalol. Both isomers have similar Class III antiarrhythmic effects, while the l-isomer is responsible for virtually all of the beta-blocking activity.

Mechanism Of Action

If it is almost time for your next dose, take only that dose. Do not take this medicine with any of the following:amoxapine , arsenic trioxide , certain antibiotics like gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin, sparfloxacin, telithromycin , cisapride , droperidol , haloperidol , hawthorn , levomethadyl , maprotiline , medicines for malaria like chloroquine and halofantrine , medicines to control heart rhythm , methadone , other beta-blockers like atenolol, metoprolol, propranolol and others , pentamidine , phenothiazines like prochlorperazine, perphenazine, thioridazine, and others , pimozide , ranolazine , tricyclic antidepressants like amitriptyline, imipramine, nortriptyline, and others , vardenafil , ziprasidone .This

Betapace Box Warning

For detailed instructions regarding dose selection and special cautions for people with renal impairment, see DOSAGE AND ADMINISTRATION. Sotalol is also indicated for the maintenance of normal sinus rhythm [delay in time to recurrence of atrial fibrillation/atrial flutter (AFIB/AFL)] in patients with symptomatic AFIB/AFL who are currently in sinus rhythm and is marketed under the brand name Betapace AF.

Betapace Warnings

Excessive prolongation of the QT interval (550 msec) can promote serious arrhythmias and should be avoided Sinus bradycardia (heart rate less than 50 bpm) occurred in 13% of patients receiving Betapace in clinical trials, and led to discontinuation in about 3% of patients. Bradycardia itself increases the risk of Torsade de Pointes. Sinus pause, sinus arrest and sinus node dysfunction occur in less than 1% of patients.

Betapace Adverse Reactions

While taking beta-blockers, patients with a history of anaphylactic reaction to a variety of allergens may have a more severe reaction on repeated challenge, either accidental, diagnostic or therapeutic. During premarketing trials, 3186 patients with cardiac arrhythmias (1363 with sustained ventricular tachycardia) received oral Betapace, of whom 2451 received the drug for at least two weeks. Foreign marketing experience with sotalol hydrochloride shows an adverse experience profile similar to that described above from clinical trials. The most common signs to be expected are bradycardia, congestive heart failure, hypotension, bronchospasm and hypoglycemia. In cases of massive intentional overdosage (2-16 grams) of Betapace the following clinical findings were seen: hypotension, bradycardia, cardiac asystole, prolongation of QT interval, Torsade de Pointes, ventricular tachycardia, and premature ventricular complexes.