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other antibiotics, Biaxin may cause a potentially life-threatening form of diarrhea that signals a condition called pseudomembranous colitis (inflammation of the large intestine). If Biaxin is taken with certain other drugs, the effects of either can be increased, decreased, or altered. If you are pregnant or plan to become pregnant, notify your doctor immediately. Since Biaxin may have the potential to cause birth defects, it is prescribed during pregnancy only when there is no alternative. An additional 14 days of 400 mg twice daily is recommended for ulcer healing and symptom relief.
Clarithromycin Recommended Dosagedose for children older than 6 months depends on how much the child weighs. Biaxin is usually given twice a day for 10 days.BIAXIN XLAdultsSinusitis: The usual dosage is 1000 milligrams once a day for 14 days.Bronchitis If you suspect an overdose, seek medical attention immediately. Do not take Biaxin if you have ever had an allergic reaction to it, or if you are sensitive to it or erythromycin, or similar antibiotics such as Tao and Zithromax. PrecautionsErythromycin has been reported to decrease the clearance of triazolam and midazolam, and thus, may increase the pharmacologic effect of these benzodiazepines. As with other macrolides, clarithromycin has been reported to increase concentrations of HMG-CoA reductase inhibitors (e.g., lovastatin and simvastatin). A similar interaction may occur with clarithromycin; reduction of sildenafil dosage should be considered. There have been spontaneous or published reports of CYP3A based interactions of erythromycin and/or clarithromycin with cyclosporine, carbamazepine, tacrolimus, alfentanil, disopyramide, rifabutin, quinidine, methylprednisolone, cilostazol, and bromocriptine. Clarithromycin Adverse ReactionsMost of these events were described as mild or moderate in severity. Of the reported adverse events, less than 1% were described as severe. In the acute exacerbation of chronic bronchitis and acute maxillary sinusitis studies overall gastrointestinal adverse events were reported by a similar proportion of patients taking either Biaxin tablets or Biaxin XL tablets; however, patients taking Biaxin XL tablets reported significantly less severe gastrointestinal symptoms compared to patients taking Biaxin tablets. In addition, patients taking Biaxin XL tablets had significantly fewer premature discontinuations for drug-related gastrointestinal or abnormal taste adverse events compared to Biaxin tablets. Biaxin Drug InteractionsThere have been post-marketing reports of torsades de pointes occurring with concurrent use of clarithromycin and quinidine or disopyramide. Electrocardiograms should be monitored for QTc prolongation during coadministration of clarithromycin with these drugs. Overdosage of clarithromycin can cause gastrointestinal symptoms such as abdominal pain, vomiting, nausea, and diarrhea. Adverse reactions accompanying overdosage should be treated by the prompt elimination of unabsorbed drug and supportive measures. |
