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Generic Canasa Mesalamine 400mg

Mesalamine is used to treat the pain and inflammation caused by ulcerative colitis. Canasa (mesalamine) is a rectal suppository that has been approved by the FDA for the treatment of active ulcerative proctitis. Ulcerative proctitis is a less severe form of ulcerative colitis - a disease that causes inflammation and ulcers in the top layers of the lining of the large intestine. Ulcerative proctitis differs from ulcerative colitis in terms of where the inflammation occurs. In ulcerative proctitis, inflammation is only present in the rectum, and the upper limit of inflammation is visible via sigmoidoscopy.

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Dosage And Administration

While the effect of Canasa Suppositories may be seen within three to twenty-one days, the usual course of therapy would be from three to six weeks depending on symptoms and sigmoidoscopic findings. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine except on the advice of your doctor or health care professional.Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.Overdosage: Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not crush or chew. The suppository should be retained for one to three hours or longer, if possible, to achieve the maximum benefit.

Mesalamine Additional Information

In a clinical trial most patients who were hypersensitive to sulfasalazine were able to take mesalamine enemas without evidence of any allergic reaction. Nevertheless, caution should be exercised when mesalamine is initially used in patients known to be allergic to sulfasalazine. These patients should be instructed to discontinue therapy if signs of rash or fever become apparent. A small proportion of patients have developed pancolitis while using mesalamine. However, extension of upper disease boundary and/or flare-ups occurred less often in the mesalamine-treated group than in the placebo-treated group. Rare instances of pericarditis have been reported with mesalamine containing products including sulfasalazine.

Canasa Precautions

Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Digoxin.This list may not describe all possible interactions. Also tell them if you smoke, drink alcohol, or use illegal drugs. Mesalamine was not mutagenic in the Ames test, the mouse lymphoma cell (TK) forward mutation test, or the mouse micronucleus test. No effects on fertility or reproductive performance of the male and female rats were observed at oral mesalamine doses up to 320 mg/kg/day (about 1.7 times the recommended human intra-rectal dose, based on body surface area).

What May Interact With This Medicine?

Teratology studies have been performed in rats at oral doses up to 320 mg/kg/day (about 1.7 times the recommended human intra-rectal dose, based on body surface area) and in rabbits at oral doses up to 495 mg/kg/day (about 5.4 times the recommended human intra-rectal dose, based on body surface area) and have revealed no evidence of impaired fertility or harm to the fetus due to mesalamine. There are, however, no adequate and well controlled studies in pregnant women. Side effects that you should report to your doctor or health care professional as soon as possible:allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue , bloody diarrhea , chest pain , difficulty breathing, wheezing , fever , pain or difficulty passing urine , unusually weak or tired , yellowing of the eyes or skin .Side

What Should I Watch For While Using This Medicine?

All brands do not have the same dose.You may notice the empty shell from this medicine in your stool. There is usually an improvement in 3 to 21 days. You may need about 6 weeks of treatment to get good results.Do It is not known whether mesalamine or its metabolite(s) are excreted in human milk. not change the brand of this medicine that you are taking without talking to your doctor or health care professional. Tell your doctor or health care professional if your symptoms do not start to get better after several days.