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Generic Cardura Doxazosin 4mg

In vitro data in human plasma indicate that Cardura has no effect on protein binding of digoxin, warfarin, phenytoin or indomethacin. There is no information on the effect of other highly plasma protein bound drugs on doxazosin binding. Cardura has been administered without any evidence of an adverse drug interaction to patients receiving thiazide diuretics, beta-blocking agents, and nonsteroidal anti-inflammatory drugs. In a placebo-controlled trial in normal volunteers, the administration of a single 1 mg dose of doxazosin on day 1 of a four-day regimen of oral cimetidine (400 mg twice daily) resulted in a 10% increase in mean AUC of doxazosin (p=0.006), and a slight but not statistically significant increase in mean C max and mean half-life of doxazosin.

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Cardura Adverse Reactions

Studies in rats showed reduced fertility in males treated with doxazosin at oral doses of 20 (but not 5 or 10) mg/kg/day, about 4 times the AUC exposures obtained with a 12 mg/day human dose. This effect was reversible within two weeks of drug withdrawal. The incidence rates presented below are based on combined data from seven placebo-controlled trials involving once daily administration of Cardura (doxazosin mesylate) in doses of 1-16 mg in hypertensives and 0.5-8 mg in normotensives.

Cardura Overdosage

Experience with Cardura overdosage is limited. Two adolescents who each intentionally ingested 40 mg Cardura with diclofenac or acetaminophen, were treated with gastric lavage with activated charcoal and made full recoveries. A two-year-old child who accidently ingested 4 mg Cardura was treated with gastric lavage and remained normotensive during the five-hour emergency room observation period. A six-month-old child accidentally received a crushed 1 mg tablet of Cardura and was reported to have been drowsy. A 32-year-old female with chronic renal failure, epilepsy and depression intentionally ingested 60 mg Cardura (blood level 0.9 mg/mL; normal values in hypertensives=0.02 mg/mL); death was attributed to a grand mal seizure resulting from hypotension.

The adverse events when the incidence in the Cardura group was at least 1% are summarized in Table 3. The oral LD 50 of doxazosin is greater than 1000 mg/kg in mice and rats. The most likely manifestation of overdosage would be hypotension, for which the usual treatment would be intravenous infusion of fluid. A 39-year-old female who ingested 70 mg Cardura, alcohol and Dalmane (flurazepam) developed hypotension which responded to fluid therapy. The incidence of adverse events has been ascertained from worldwide clinical trials in 965 BPH patients. No significant difference in the incidence of adverse events compared to placebo was seen except for dizziness, fatigue, hypotension, edema and dyspnea.