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Generic Cataflam Diclofenac 50mg

These serious events may occur without warning. Do not take this medicine with any of the following:cidofovir , ketorolac , methotrexate , pemetrexed .This medicine may also interact with the following:alcohol , aspirin and aspirin-like medicines , diuretics , lithium , medicines for high blood pressure , medicines that affect platelets , medicines that treat or prevent blood clots like warfarin , NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen , steroid medicines like prednisone or cortisone.This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus, rashes and tinnitus.

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Cataflam Precautions

In a 6-month, double-blind trial comparing Cataflam versus Voltaren (diclofenac sodium delayed-release tablets) versus ibuprofen adverse reactions were similar in nature and frequency. NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. Cataflam, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID.

Cataflam Drug Interactions

Therefore, concomitant therapy with Cataflam may increase cyclosporine's nephrotoxicity. Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors. NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. Symptoms following acute NSAID overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur.

Cataflam Overdosage

This may indicate that they could enhance the toxicity of methotrexate. This response has been attributed to inhibition of renal prostaglandin synthesis. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare. The mean minimum lithium concentration increased 15% and the renal clearance was decreased by approximately 20%. Clinical studies, as well as post-marketing observations, have shown that Cataflam can reduce the natriuretic effect of furosemide and thiazides in some patients. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs, and may occur following an overdose. Patients should be managed by symptomatic and supportive care following an NSAID overdose. There are no specific antidotes.