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Familial Adenomatous Polyposis The recommended dose is 400 milligrams twice a day with food. Ankylosing Spondylitis The recommended dose is 200 milligrams once a day, or 100 milligrams twice a day. If there is no effect after 6 weeks, the doctor may increase your dose to 400 milligrams. Any medication taken in excess can have serious consequences. Only one in five patients who develop a serious upper GI adverse event on NSAID therapy is symptomatic. Complicated and symptomatic ulcer rates were 0.78% at nine months for all patients in the CLASS trial, and 2.19% for the subgroup on low dose ASA.

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Celebrex Uses

Fluid retention and edema have been observed in some patients taking NSAIDs, including Celebrex In the CLASS study the Kaplan-Meier cumulative rates at 9 months of peripheral edema in patients on Celebrex 400 mg twice daily (4-fold and 2-fold the recommended OA and RA doses, respectively, and the approved dose for FAP), ibuprofen 800 mg three times daily and diclofenac 75 mg twice daily were 4.5%, 6.9% and 4.7%, respectively. NSAIDs, including Celebrex, can cause serious gastrointestinal events including bleeding, ulceration, and perforation of the stomach, small intestine or large intestine, which can be fatal.

Celebrex Missed Dose

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of an NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, angiotensin II receptor antagonists, and the elderly.

Adverse Reactions Which Occur Rarely

Kaplan-Meier cumulative rates at 9 months for withdrawals due to adverse events for Celebrex, diclofenac and ibuprofen were 24%, 29%, and 26%, respectively. The most commonly occurring (greater than 5%) adverse events in celecoxib treated patients were headache, fever (pyrexia), upper abdominal pain, cough, nasopharyngitis, abdominal pain, nausea, arthralgia, diarrhea and vomiting. The most commonly occurring (greater than 5%) adverse experiences for naproxen treated patients were headache, nausea, vomiting, fever, upper abdominal pain, diarrhea, cough, abdominal pain, and dizziness Compared with naproxen, celecoxib at doses of 3 and 6 mg/kg BID had no observable deleterious effect on growth and development during the course of the 12-week double-blind study.

Celebrex Drug Interactions

A total of 378 patients were treated with Celebrex in placebo- and active- controlled ankylosing spondylitis studies. Doses up to 400 mg QD were studied. Approximately 1,700 patients were treated with Celebrex in analgesia and dysmenorrhea studies. All patients in post-oral surgery pain studies received a single dose of study medication. Doses up to 600 mg/day of Celebrex were studied in primary dysmenorrhea and post-orthopedic surgery pain studies.