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Generic Clorpres 0.1mg + 15

This fixed combination drug is not indicated for initial therapy of hypertension. Hypertension requires therapy titrated to the individual patient. Clorpres(clonidine hydrochloride USP/chlorthalidone USP) is indicated in the treatment of hypertension. If the fixed combination represents the dosage so determined, its use may be more convenient in patient management. Clorpresis a combination of clonidine hydrochloride (a centrally acting antihypertensive agent) and chlorthalidone (a diuretic). Clorpresis available as tablets for oral administration in three dosage strengths: 0.1 mg/15 mg, 0.2 mg/15 mg and 0.3 mg/15 mg of clonidine hydrochloride/chlorthalidone, respectively.

Package	Price	Per Pill	Order
0.1mg + 15mg × 30 pills	$49.20	US $ 1.64
0.1mg + 15mg × 60 pills	$56.40	US $ 0.94
0.1mg + 15mg × 90 pills	$63.60	US $ 0.71
0.1mg + 15mg × 120 pills	$70.80	US $ 0.59
0.1mg + 15mg × 180 pills	$85.20	US $ 0.47
0.1mg + 15mg × 360 pills	$128.40	US $ 0.36

Dosage And Administration

Clonidine hydrochloride is usually initiated at a dose of 0.1 mg twice daily. Elderly patients may benefit from a lower initial dose. Further increments of 0.1 mg/day may be made if necessary until the desired response is achieved. The dosage must be determined by individual titration. Chlorthalidone is usually initiated at a dose of 25 mg once daily and may be increased to 50 mg if the response is insufficient after a suitable trial. The therapeutic doses most commonly employed have ranged from 0.2 to 0.6 mg per day in divided doses.

Warnings

In patients with renal disease, chlorthalidone or related drugs may precipitate azotemia. Cumulative effects of the drug may develop in patients with impaired renal function. Chlorthalidone should be used with caution in patients with impaired hepatic function or progressive liver disease, because minor alterations of fluid and electrolyte balance may precipitate hepatic coma. Sensitivity reactions may occur in patients with a history of allergy or bronchial asthma. Chlorthalidone should be used with caution in severe renal disease. The possibility of exacerbation or activation of systemic lupus erythematosus has been reported with thiazide diuretics which are structurally related to chlorthalidone.

Overdosage

Clonidine Hydrochloride: The signs and symptoms of clonidine hydrochloride overdosage include hypotension, bradycardia, lethargy, irritability, weakness, somnolence, diminished or absent reflexes, miosis, vomiting and hypoventilation. With large overdoses, reversible cardiac conduction defects or arrhythmias, apnea, seizures and transient hypertension have been reported. The oral LD 50 of clonidine in rats was 465 mg/kg, and in mice 206 mg/kg. The general treatment of clonidine hydrochloride overdosage may include intravenous fluids as indicated. Bradycardia can be treated with intravenous atropine sulfate and hypotension with dopamine infusion in addition to intravenous fluids.