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Generic Clozaril Clozapine 25/100mg

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. This medicine may be taken with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not suddenly stop taking this medicine. You may need to gradually reduce the dose. The exact medication plan for a patient undergoing therapy with Clozaril will be determined by the examining health care professional. The treatment typically consists of one or two daily intakes of the recommended doses, but may change during the course of the therapy.

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Where Should I Keep This Medicine?

Keep out of the reach of children.Store ADULTS Your doctor will carefully individualize your dosage and monitor your response regularly. The usual recommended initial dose is half of a 25-milligram tablet (12.5 milligrams) 1 or 2 times daily. Any medication taken in excess can have serious consequences. This medication is used to treat certain mental/mood disorders (schizophrenia, schizoaffective disorders). However, a disproportionate number of the U.S. cases of agranulocytosis occurred in patients of Jewish background compared to the overall proportion of such patients exposed during domestic development of Clozaril (clozapine). US residents can call the US national poison hotline at 1-800-222-1222.

Warnings

Only stop taking this medicine on the advice of your doctor or health care professional.Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.Note: This medicine is only for you. Allow the tablets to dissolve on your tongue and swallow. You do not need to take the dissolving tablets with water. Discard any dissolving tablets that have been previously exposed to air due to opened/damaged packaging.

How To Use Clozaril Oral

Analysis of WBC count data from the Clozaril National Registry also suggests that patients who have an initial episode of moderate leukopenia (3000/mm greater than WBC greater than 2000/mm ) are at an increased risk of subsequent episodes of agranulocytosis. Except for bone marrow suppression during initial Clozaril (clozapine) therapy, there are no other established risk factors, based on worldwide experience, for the development of agranulocytosis in association with Clozaril (clozapine) use. The text that follows should be consulted for additional details regarding the treatment of patients under the various conditions (e.g., severe leukopenia).

Incidence In Clinical Trials

Urogenital System: dysmenorrhea, impotence, breast pain/discomfort, and vaginal itch/infection. Autonomic Nervous System: numbness, polydipsia, hot flashes, dry throat, and mydriasis. Integumentary (Skin): pruritus, pallor, eczema, erythema, bruise, dermatitis, petechiae, and urticaria. Musculoskeletal System: twitching and joint pain. Respiratory System: coughing, pneumonia/pneumonia-like symptoms, rhinorrhea, hyperventilation, wheezing, bronchitis, laryngitis, and sneezing. The mechanism of Clozaril-induced agranulocytosis is unknown; nonetheless, the possibility that causative factors may interact synergistically to increase the risk and/or severity of bone marrow suppression warrants consideration. Therefore, Clozaril should not be used with other agents having a well-known potential to suppress bone marrow function.