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Side effects that you should report to your doctor or health care professional as soon as possible:breathing difficulties , depression , fever, chills, or sore throat , muscle aches, pains, weakness , pain, tingling, numbness in the hands or feet , seizures , unusual bruising or bleeding , unusually weak or tired , weight gain around waist, back, or thinning of face, arms, legs .Side Talk to your doctor about how to stop the spread of HIV.If you have hepatitis B, talk to your doctor if you plan to stop or change your therapy.

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Recommended Daily Dose

Combivir comes in tablet form and is taken by mouth. The recommended dose of Combivir for adults and children at least 12 years of age is one tablet (150 mg lamivudine and 300 mg zidovudine) twice a day. Some patients may require a different dose of lamivudine or zidovudine. These patients should not take Combivir.

Adverse Reactions

Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The effect of higher doses of TMP/SMX on lamivudine pharmacokinetics has not been investigated No data are available regarding the potential for interactions with other drugs that have renal clearance mechanisms similar to that of lamivudine. Lamivudine and zalcitabine may inhibit the intracellular phosphorylation of one another. In addition to adverse events reported from clinical trials, the following events have been identified during post-approval use of EPIVIR, RETROVIR, and/or Combivir.

What is known about Combivir?

Combivir is taken twice daily, one tablet in the morning and one tablet in the evening, with or without food. For HIV-positive adults beginning HIV drug therapy for the first time, Combivir is listed as an "alternative" NRTI optionused in combination with either a protease inhibitor or non-nucleoside reverse transcriptase inhibitor. Combivir must be combined with at least one other HIV drug, usually a protease inhibitor (PI) or a non-nucleoside reverse transcriptase inhibitor (NNRTI). To prevent transmission of the virus to uninfected babies, it is recommended that HIV-positive mothers not breast-feed. This medicine does not cure or prevent HIV infection or AIDS and does not reduce the risk of passing the virus to other people.