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Coumadin is an anticoagulant (blood thinner). Meta-analysis findings of these studies revealed that the effects of warfarin in reducing thromboembolic events including stroke were similar at either moderately high INR (2.0-4.5) or low INR (1.4-3.0). There was a significant reduction in minor bleeds at the low INR. Similar data from clinical studies in valvular atrial fibrillation patients are not available. The trials in non-valvular atrial fibrillation support the American College of Chest Physicians' (ACCP) recommendation that an INR of 2.0-3.0 be used for long term warfarin therapy in appropriate AF patients. Post-Myocardial Infarction: In post-myocardial infarction patients, Coumadin (Warfarin Sodium) therapy should be initiated early (2-4 weeks post-infarction) and dosage should be adjusted to maintain an INR of 2.5-3.5 long-term.
How Taken DrugDue to the anti clotting property of Coumadin, it should be administered with care and preferably under doctor's monitoring for patients who have the following medical conditions: Have recently had surgery , Ill with stomach ulcers, or any other forms of bleeding , Have had stroke caused by bleeding in the brain , Have had aneurysm , Have had spinal fracture or had been exposed to lumbar block anesthesia , Have bacterial endocarditis, pericarditis, and pericardial effusion. Drug Class And MechanismThe INR can be calculated as: INR = (observed PT ratio) where the ISI (International Sensitivity Index) is the correction factor in the equation that relates the PT ratio of the local reagent to the reference preparation and is a measure of the sensitivity of a given thromboplastin to reduction of vitamin K-dependent coagulation factors; the lower the ISI, the more "sensitive" the reagent and the closer the derived INR will be to the observed PT ratio. Take the missed dose as soon as possible if you remember on the same day. Coumadin OverdosageCheck with your doctor before taking ANY other medication or vitamin product. Be extremely cautious, too, about taking any herbal remedies and supplements. Coumadin has not been found in the breast milk of mothers taking the drug. Signs and symptoms of Coumadin overdose reflect abnormal bleeding. Coumadin can interact with a very wide variety of drugs, both prescription and over-the-counter. Spontaneous abortions and stillbirths are also known to occur. If you become pregnant while taking this drug, inform your doctor immediately. |
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