women's health / Generic Diflucan

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Generic Diflucan

Generic Diflucan

Fluconazole 50/100/150/200mg

Take the missed dose as soon as you remember. Do not take Diflucan if you are sensitive to any of its ingredients or have ever had an allergic reaction to similar drugs, such as ketoconazole. Make sure your doctor is aware of any drug reactions you have experienced. If Diflucan is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical treatment immediately.

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What Happens If I Overdose?

Do not take Diflucan if you are sensitive to any of its ingredients or have ever had an allergic reaction to similar drugs, such as ketoconazole. Make sure your doctor is aware of any drug reactions you have experienced.Avoid combining Diflucan with the heartburn medication cisapride. If you are pregnant or plan to become pregnant, inform your doctor immediately. A dosage of 400 mg once daily may be used, based on medical judgment of the patient's response to therapy.

Diflucan Precautions

Diflucan increases the plasma concentrations of phenytoin. Diflucan may significantly increase cyclosporine levels in renal transplant patients with or without renal impairment. Another study at a 400-mg and 800-mg daily dose of fluconazole demonstrated that Diflucan taken in doses of 400 mg per day or greater significantly increases plasma levels of terfenadine when taken concomitantly. The combined use of fluconazole at doses of 400 mg or greater with terfenadine is contraindicated. A controlled study found that concomitant fluconazole 200 mg once daily and cisapride 20 mg four times a day yielded a significant increase in cisapride plasma levels and prolongation of QTc interval.

Diflucan Adverse Reactions

Diflucan increases the serum concentrations of theophylline. One study at a 200-mg daily dose of fluconazole failed to demonstrate a prolongation in QTc interval. The overall incidence of side effects possibly related to Diflucan was 26%. In 422 patients receiving active comparative agents, the incidence was 16%. The most common treatment-related adverse events reported in the patients who received 150 mg single dose fluconazole for vaginitis were headache (13%), nausea (7%), and abdominal pain (6%).

Adverse Reactions In Children

Treatment was discontinued in 1.5% of patients due to adverse clinical events and in 1.3% of patients due to laboratory test abnormalities. Clinical adverse events were reported more frequently in HIV infected patients (21%) than in non-HIV infected patients (13%); however, the patterns in HIV infected and non-HIV infected patients were similar. The proportions of patients discontinuing therapy due to clinical adverse events were similar in the two groups (1.5%). In Phase II/III clinical trials conducted in the United States and in Europe, 577 pediatric patients, ages 1 day to 17 years were treated with Diflucan at doses up to 15 mg/kg/day for up to 1,616 days. Thirteen percent of children experienced treatment related adverse events.

Fluconazole Drug Interactions

The spectrum of these hepatic reactions has ranged from mild transient elevations in transaminases to clinical hepatitis, cholestasis and fulminant hepatic failure, including fatalities. Instances of fatal hepatic reactions were noted to occur primarily in patients with serious underlying medical conditions (predominantly AIDS or malignancy) and often while taking multiple concomitant medications. Transient hepatic reactions, including hepatitis and jaundice, have occurred among patients with no other identifiable risk factors. In each of these cases, liver function returned to baseline on discontinuation of Diflucan. In two comparative trials evaluating the efficacy of Diflucan for the suppression of relapse of cryptococcal meningitis, a statistically significant increase was observed in median AST (SGOT) levels from a baseline value of 30 IU/L to 41 IU/L in one trial and 34 IU/L to 66 IU/L in the other.

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