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Generic Diltiazem Diltiazem hcl 60/90/120mg

Cardizem belongs to the kind of drugs called calcium channel blockers. Talk to your doctor first before taking Cardizem if you have or have had an allergic reaction to any form of Cardizem, kidney disease, liver disease, and other diseases of the blood vessels or heart like sinus syndrome, aortic stenosis, congestive heart failure, heart block, low blood pressure, or coronary artery disease. In case you have the said conditions, your doctor might not allow you to take Cardizem, adjust your dose, or require you a special monitoring during the treatment with this drug.

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Diltiazem Hcl Cardizem Indications

The two forms of the drug were shown to have similar trends in half-life, despite the difference in absorption rate. It should be swallowed completely. If it is difficult for you to swallow Tiazac capsule, you may open it and sprinkle the content into a spoonful of applesauce. Without chewing it, the applesauce should be swallowed immediately. A glass of water should follow it after swallowing to make sore that you consume the whole content of the capsule. To be able to swallow the applesauce without chewing it, make sure that it is soft and it is not hot. You must take the mixture immediately. Do not keep it for later use.

Warnings

Some of the symptoms of overdose with Cardizem are dizziness, weakness, chest pain, shortness of breath, fainting, unusually fast or slow heartbeat, coma, slurred speech, and confusion. In case you experience any of the said serious side effects, stop taking Cardizem, look for emergency medical attention, or contact your doctor immediately. Diltiazem is excreted in human milk. One report with oral diltiazem suggests that concentrations in breast milk may approximate serum levels.

Diltiazem Cardizem Overdose

These pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effects (e.g., prolonged sedation) of both midazolam and triazolam. Beta-blockers. Intravenous diltiazem has been administered to patients on chronic oral beta-blocker therapy. The combination of the two drugs was generally well tolerated without serious adverse effects. If intravenous diltiazem is administered to patients receiving chronic oral beta-blocker therapy, the possibility for bradycardia, AV block, and/or depression of contractility should be considered Oral administration of diltiazem with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%.

Overdosage

High-degree AV Block: Treat as for bradycardia above. Fixed high-degree AV block should be treated with cardiac pacing. Cardiac Failure: Administer inotropic agents (isoproterenol, dopamine, or dobutamine) and diuretics. Hypotension: Vasopressors (e.g., dopamine or levarterenol bitartrate). The effectiveness of intravenous calcium administration to reverse the pharmacological effects of diltiazem overdose has been inconsistent. In a few reported cases, overdose with calcium channel blockers associated with hypotension and bradycardia that was initially refractory to atropine became more responsive to atropine after the patients received intravenous calcium.

In some cases intravenous calcium has been administered (1 g calcium chloride or 3 g calcium gluconate) over 5 minutes, and repeated every 10-20 minutes as necessary. Calcium gluconate has also been administered as a continuous infusion at a rate of 2 g per hour for 10 hours. Infusions of calcium for 24 hours or more may be required. Patients should be monitored for signs of hypercalcemia. Actual treatment and dosage should depend on the severity of the clinical situation and the judgment and experience of the treating physician.