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Generic Dostinex Cabergoline 0.25/0.5mg

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Dostinex Clinical Results

In a clinical trial involving approximately 450 subjects, Dostinex was compared with bromocriptine in treating hyperporlactinemia. Each tablet is scored on one side and has the letter P and the letter U on either side of the breakline. The other side of the tablet is engraved with the number 700. Hyperprolactinemia is usually caused by a benign tumor on the pituitary gland that results in excess production of prolactin, the hormone that controls lactation. Macrolides, butyrophenones, metoclopramide, phenothiazines, thioxanthenes. Side effects that you should report to your doctor or health care professional as soon as possible: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue), behavior changes (eg, aggression, increased gambling or sexual urges), chest pain, hallucinations, irregular heartbeat, shortness of breath, sudden unexplained weight gain, swelling of hands or feet, vision disturbances, depression, cough.

What Side Effects May I Notice From This Medicine?

Dostinex is not indicated for the inhibition or suppression of physiologic lactation. Chest x-ray examination is recommended in cases of unexplained ESR increases to abnormal values. Pathological gambling, increased libido, and hypersexuality have been reported in patients treated with dopamine agonists including cabergoline. Patients should be instructed to notify their physician if they suspect they are pregnant, become pregnant, or intend to become pregnant during therapy. In rats, there was a slight increase in malignant tumors of the cervix and uterus and interstitial cell adenomas. The occurrence of tumors in female rodents may be related to the prolonged suppression of prolactin secretion because prolactin is needed in rodents for the maintenance of the corpus luteum.

Dostinex Precautions

Some reports were in patients previously treated with ergotinic dopamine agonists. Dostinex should not be used in patients with a history of, or current signs and or clinical symptoms of, respiratory or cardiac disorders linked to fibrotic tissue. Following diagnosis of pleural effusion or pulmonary fibrosis, the discontinuance of cabergoline has been reported to result in improvement of signs and symptoms. Erythrocyte sedimentation rate (ESR) has been found to be abnormally increased in association with pleural effusion/fibrosis. In male rodents, the decrease in serum prolactin levels was associated with an increase in serum luteinizing hormone, which is thought to be a compensatory effect to maintain testicular steroid synthesis.

Dostinex Adverse Reactions

These tests included the bacterial mutation (Ames) test with Salmonella typhimurium, the gene mutation assay with Schizosaccharomyces pombe P 1 and V79 Chinese hamster cells, DNA damage and repair in Saccharomyces cerevisiae D 4, and chromosomal aberrations in human lymphocytes. Cabergoline was also negative in the bone marrow micronucleus test in the mouse. In female rats, a daily dose of 0.003 mg/kg for 2 weeks prior to mating and throughout the mating period inhibited conception. There were maternotoxic effects but no teratogenic effects in mice given cabergoline at doses up to 8 mg/kg/day (approximately 55 times the maximum recommended human dose) during the period of organogenesis.