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Generic Epivir-hbv Lamivudine 150mg

If you miss a dose, take it as soon as you can. Also tell them if you smoke, drink alcohol, or use illegal drugs. Epivir-Hbv Tablets and Oral Solution contain a lower dose of the same active ingredient (lamivudine) as EPIVIR Tablets and Oral Solution, COMBIVIR (lamivudine/zidovudine) Tablets, and TRIZIVIR (abacavir, lamivudine, and zidovudine) Tablets used to treat HIV infection. The formulation and dosage of lamivudine in Epivir-Hbv are not appropriate for patients dually infected with HBV and HIV. Clinical and laboratory evidence of exacerbations of hepatitis have occurred after discontinuation of Epivir-Hbv (these have been primarily detected by serum ALT elevations, in addition to the re-emergence of HBV DNA commonly observed after stopping treatment; see Table 7 for more information regarding frequency of posttreatment ALT elevations).

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What If I Miss A Dose?

If it is almost time for your next dose, take only that dose. The recommended oral dose of Epivir-Hbv for pediatric patients 2 to 17 years of age with chronic hepatitis B is 3 mg/kg once daily up to a maximum daily dose of 100 mg. Side effects that you should report to your doctor or health care professional as soon as possible:allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue , breathing difficulties , depressed mood , muscle pain or weakness , nausea, vomiting, unusual stomach upset or pain , pain, tingling, numbness in the hands or feet , unusually weak or tired , yellowing of the skin or eyes .Side

Epivir-Hbv Precautions

Lamivudine-treated patients (adult and pediatric) with YMDD-mutant HBV at 52 weeks showed diminished treatment responses in comparison to lamivudine-treated patients without evidence of YMDD mutations, including lower rates of HBeAg seroconversion and HBeAg loss (no greater than placebo recipients), more frequent return of positive HBV DNA by solution-hybridization or branched-chain DNA assay, and more frequent ALT elevations. Patients should be advised that Epivir-Hbv is not a cure for hepatitis B, that the long-term treatment benefits of Epivir-Hbv are unknown at this time, and, in particular, that the relationship of initial treatment response to outcomes such as hepatocellular carcinoma and decompensated cirrhosis is unknown.

Lamivudine Adverse Reactions

They should discuss any new symptoms or concurrent medications with their physician. Lamivudine is predominantly eliminated in the urine by active organic cationic secretion. The possibility of interactions with other drugs administered concurrently should be considered, particularly when their main route of elimination is active renal secretion via the organic cationic transport system (e.g., trimethoprim). TMP 160 mg/SMX 800 mg once daily has been shown to increase lamivudine exposure (AUC) by 44% No change in dose of either drug is recommended. In clinical trials using lamivudine as part of a combination regimen for treatment of HIV infection, several clinical adverse events occurred more often in lamivudine-containing treatment arms than in comparator arms.

Epivir-Hbv Drug Interactions

The following events have been identified during post-approval use of lamivudine in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. Pregnancy Category C. Reproduction studies have been performed in rats and rabbits at orally administered doses up to 4,000 mg/kg/day and 1,000 mg/kg/day, respectively, producing plasma levels up to approximately 60 times that for the adult HBV dose. No evidence of teratogenicity due to lamivudine was observed. Evidence of early embryolethality was seen in the rabbit at exposure levels similar to those observed in humans, but there was no indication of this effect in the rat at exposures up to 60 times that in humans.