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Contact your local poison control centre and alert your personal physician. If necessary, go to the nearest emergency room to receive the proper treatment for your condition. After a mean follow-up of 5.6 years during the clinical trial, the overall relative risk of invasive breast cancer was 1.24 (95% confidence interval 1.01 - 1.54), and the overall absolute risk was 41 vs 33 cases per 10,000 women-years for CE/MPA compared with placebo. Among women who reported prior use of hormone therapy, the relative risk of invasive breast cancer was 1.86, and the absolute risk was 46 vs 25 cases per 10,000 women-years for CE/MPA compared with placebo.
WarningsIf you think that you might be experiencing an overdose with Estrace, you should seek medical care at once. The reported endometrial cancer risk among unopposed estrogen users is about 2- to 12-fold greater than in non-users, and appears dependent on duration of treatment and on estrogen dose. Most studies show no significant increased risk associated with use of estrogens for less than one year. In the same substudy, invasive breast cancers were larger and diagnosed at a more advanced stage in the CE/MPA group compared with the placebo group. Metastatic disease was rare with no apparent difference between the two groups. Other prognostic factors such as histologic subtype, grade and hormone receptor status did not differ between the groups. How Should I Use This Medicine?patient information sheet will be given with each prescription and refill. Read this sheet carefully each time. Serious ill effects have not been reported following acute ingestion of large doses of estrogen-containing drug products by young children. Side effects that you should report to your doctor or health care professional as soon as possible:allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue , breast tissue changes or discharge , changes in vision , chest pain , confusion, trouble speaking or understanding , dark urine , general ill feeling or flu-like symptoms , light-colored stools , nausea, vomiting , pain, swelling, warmth in the leg , right upper belly pain , severe headaches , shortness of breath , sudden numbness or weakness of the face, arm or leg , trouble walking, dizziness, loss of balance or coordination , unusual vaginal bleeding , yellowing of the eyes or skin .Side What If I Miss A Dose?medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.This What May Interact With This Medicine?Do not take this medicine with any of the following:aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone .This medicine may also interact with the following:carbamazepine , certain antibiotics used to treat infections , certain barbiturates or benzodiazepines used for inducing sleep or treating seizures , grapefruit juice , medicines for fungus infections like itraconazole and ketoconazole , raloxifene or tamoxifen , rifabutin, rifampin, or rifapentine , ritonavir , St. John's Wort , warfarin.This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. |
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