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Generic Femara Letrozole 2.5mg

Inform your doctor about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products and whether you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. Femara drug label information in our database does not contain a dedicated section on drug interactions. Visit your doctor or health care professional for regular check-ups to monitor your condition. Do not use this drug if you are pregnant. Serious side effects to an unborn child are possible.

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Femara General Information

Femara blocks the formation of the hormone estrogen. Some types of Breast Cancer need estrogen, and letrozole stops tumor growth by decreasing estrogen levels. Talk to your pediatrician regarding the use of this medicine in children. Pregnancy: Letrozole may cause fetal harm when administered to pregnant women. Studies in rats at doses equal to or greater than 0.003 mg/kg (about 1/100 the daily maximum recommended human dose on a mg/m basis) administered during the period of organogenesis, have shown that letrozole is embryotoxic and fetotoxic, as indicated by intrauterine mortality, increased resorption, increased postimplantation loss, decreased numbers of live fetuses and fetal anomalies including absence and shortening of renal papilla, dilation of ureter, edema and incomplete ossification of frontal skull and metatarsals.

Femara Side Effects

No dose adjustment is required for elderly patients. Patients treated with Femara do not require glucocorticoid or mineralocorticoid replacement therapy. Renal Impairment: No dosage adjustment is required for patients with renal impairment if creatinine clearance is greater than /=10 mL/min. Fetal anomalies included incomplete ossification of the skull, sternebrae, and fore- and hindlegs. There are no studies in pregnant women. Also tell them if you smoke, drink alcohol, or use illegal drugs. If you would like more information on this product, please visit the Femara web site. The common side effects of Femara found are: difficulty in breathing;chest pain; leg pain or swelling; skin rash. Side effects that usually do not require medical attention are: back or bone pain; cough, or throat infection; diarrhea or constipation; dizziness; headache; hair loss; hot flashes; loss of appetite; nausea, vomiting; stomach pain or upset stomach; sweating; weakness or tiredness; weight gain.

Femara Usage Guidelines

Take Femara tablets by mouth at the same time each day. Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): bone, back, joint, or muscle pain, dizziness, flushing, increased sweating, headache, hot flashes, night sweats, loss of appetite, nausea, sleeplessness, stomach pain, tiredness or weakness, weight gain or loss. You may get drowsy or dizzy. In contrast to ovariectomy, treatment with letrozole does not lead to an increase in serum FSH. This medicine may also interact with the following: dietary supplements such as androstenedione or DHEA, prasterone, tamoxifen.

Femara Clinical Results

Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching, or hives, bone fracture, chest pain, difficulty breathing or shortness of breath, severe pain, swelling, warmth in the leg, unusually weak or tired, urinary tract infection, vision or speech changes, swelling of the ankles or feet. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens.

What Should I Watch For While Using This Medicine?

In adult non-tumor and tumor-bearing female animals, letrozole is as effective as ovariectomy in reducing uterine weight, elevating serum LH, and causing the regression of estrogen-dependent tumors. Letrozole selectively inhibits gonadal steroidogenesis but has no significant effect on adrenal mineralocorticoid or glucocorticoid synthesis. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues. In general, supportive care and frequent monitoring of vital signs are also appropriate. In single dose studies the highest dose used was 30 mg, which was well tolerated; in multiple dose trials, the largest dose of 10 mg was well tolerated.