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In patients who develop hypoglycemia when receiving Glucovance and a thiazolidinedione, consideration should be given to reducing the dose of the glyburide component of Glucovance. If Glucovance is taken with certain other drugs, the effects of either drug could be increased, decreased, or altered. Keep out of the reach of children.Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Keep container tightly closed and protect from light. In double-blind clinical trials involving Glucovance as initial therapy or as second-line therapy, a total of 642 patients received Glucovance, 312 received metformin therapy, 324 received glyburide therapy, and 161 received placebo. Possible Food And Drug Interactions When Taking GlucovanceIf you are sick or exercising more than usual, you might need to change the dose of your medicine. Do not skip meals. Glucovance is not recommended during pregnancy. To control blood sugar during this crucial period, most doctors prefer insulin instead of Glucovance. Treatment is combined with a diet and exercise. This anti-diabetic medication is a combination of 2 drugs (glyburide and metformin). It is used along with a diet and exercise program to control high blood sugar in patients with type 2 diabetes (non-insulin-dependent diabetes). Special Information If You Are Pregnant Or BreastfeedingCardiovascular collapse (shock) from whatever cause, acute congestive heart failure, acute myocardial infarction, and other conditions characterized by hypoxemia have been associated with lactic acidosis and may also cause prerenal azotemia. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. What Is/Are Glucovance Tablets?US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center. Overdose can cause lactic acidosis and low blood sugar. Overdosage of sulfonylureas, including glyburide tablets, can produce hypoglycemia. Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Stop taking this medication and seek immediate medical attention if you develop any of the following symptoms of lactic acidosis: unusual tiredness, severe drowsiness, chills, blue/cold skin, muscle pain, fast/difficult breathing, unusually slow/irregular heartbeat. Special Warning On Increased Risk Of Cardiovascular MortalityThe dosage is based on your medical condition and response to therapy. Your doctor may direct you to take a low dose at first, gradually increasing the dose to lower the chance of side effects such as upset stomach and low blood sugar. Your doctor will adjust your dose based on your blood sugar levels to find the best dose for you. Follow your doctor's directions carefully. The usual maximum dose for adults is 2000 milligrams of metformin and 20 milligrams of glyburide each day. If you are already taking another anti-diabetic drug (e.g., chlorpropamide), follow your doctor's directions carefully for stopping the old drug and starting this combination medication. |
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