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Generic Hydrea Hydroxyurea 500mg

Tell your health care provider if you are taking any other medicines, especially any of the following: Didanosine because the risk of side effects such as inflammation of the pancreas may be increased. Be careful in driving or operating hazardous machinery after a dose of Hydrea. Hydrea is a drug that must be well taken care of. An adequate trial period for determining the antineoplastic effectivenessof hydroxyurea is six weeks of therapy. When there is regression in tumor size or arrest in tumor growth, therapy should be continued indefinitely. Therapy should be interrupted if the white blood cell count drops below 2500/mm, or the platelet count below 100,000/mm. In these cases, the counts should be reevaluated after three days, and therapy resumed when the counts return to acceptable levels.

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Dosage And Administration

For Intermittent Therapy: 80 mg/kg of Hydrea is administered orally as a single dose every third day. All medicines may cause side effects, but many people have no, or minor, side effects. Since the hematopoietic rebound is prompt, it is usually necessary to omit only a few doses. As renal excretion is a pathway of elimination, consideration should be given to decreasing the dosage of Hydrea in patients with renal impairment. Thrombocytopenia and anemia occur less often and are seldom seen without a preceding leukopenia. Hepatotoxicity and hepatic failure resulting in death have been reported during post-marketing surveillance in HIV-infected patients treated with hydroxyurea and other antiretroviral agents.

Hydrea Intake Guidelines

Take Hydrea exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. All dosage of Hydrea is dependent on the age and ideal weight of the patient. Use the lowest effective dose of Hydrea. If prompt rebound has not occurred during combined Hydrea and irradiation therapy, irradiation may also be interrupted. Fatal and nonfatal pancreatitis have occurred in HIV-infected patients during therapy with hydroxyurea and didanosine, with or without stavudine.

Warnings

In patients receiving long-term hydroxyurea for myeloproliferative disorders, such as polycythemia vera and thrombocythemia, secondary leukemia has been reported. It is unknown whether this leukemogenic effect is secondary to hydroxyurea or is associated with the patient's underlying disease. The complete status of the blood, including bone marrow examination, if indicated, as well as kidney function and liver function should be determined prior to, and repeatedly during, treatment.

Hydroxyurea Precautions

Adverse reactions observed with combined hydroxyurea and irradiation therapy are similar to those reported with the use of hydroxyurea or radiation treatment alone. These effects primarily include bone marrow depression (anemia and leukopenia), gastric irritation, and mucositis. Almost all patients receiving an adequate course of combined hydroxyurea and irradiation therapy will demonstrate concurrent leukopenia. The determination of the hemoglobin level, total leukocyte counts, and platelet counts should be performed at least once a week throughout the course of hydroxyurea therapy.