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Generic Imitrex Sumatriptan 25mg

If your headache returns after you have had an Imitrex Injection, you may take single Imitrex Tablets, at intervals of at least 2 hours, up to a maximum of 200 milligrams in a day.Imitrex nasal spray is packaged in single-dose bottles containing either 5 or 20 milligrams of the drug. The usual dosage is a single spray in one nostril. Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible.

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Warnings

If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Because there could be an accumulation in melanin-rich tissues over time, this raises the possibility that sumatriptan could cause toxicity in these tissues after extended use. However, no effects on the retina related to treatment with sumatriptan were noted in any of the oral or subcutaneous toxicity studies. Do not share this medication with others. Certain foods/beverages or food additives (e.g., red wine, cheese, chocolate, monosodium glutamate) as well as some lifestyle patterns (e.g., irregular eating/sleeping habits, stress) may bring about a migraine headache.

How To Use Imitrex Oral

In patients taking MAO-A inhibitors, sumatriptan plasma levels attained after treatment with recommended doses are 7-fold higher following oral administration than those obtained under other conditions. Store the US product between 36-86 degrees F (2-30 degrees C) away from heat, light and moisture. Store the Canadian product at room temperature between 59 to 86 degrees F (15 to 30 degrees C) Do not store in the bathroom. Store this medication in its undamaged original packaging, and do not remove the tablet from its packaging until you are ready to take it. Many people using this medication do not have serious side effects.

Imitrex Adverse Reactions

Frequent were sinusitis, tinnitus; allergic rhinitis; upper respiratory inflammation; ear, nose, and throat hemorrhage; external otitis; hearing loss; nasal inflammation; and sensitivity to noise. Infrequent were constipation, dysphagia, and gastroesophageal reflux. Infrequent was muscle cramps. Frequent were phonophobia and photophobia. Infrequent were confusion, depression, difficulty concentrating, disturbance of smell, dysarthria, euphoria, facial pain, heat sensitivity, incoordination, lacrimation, monoplegia, sleep disturbance, shivering, syncope, and tremor. Infrequent was asthma. Average exposures achieved in mice receiving the highest dose (target dose of 160 mg/kg/day) were approximately 40 times the exposure attained in humans after the maximum recommended single oral dose of 100 mg.

Imitrex Drug Interactions

Frequent was dyspnea. Volunteers (N = 174) have received single oral doses of 140 to 400 mg without serious adverse events. Overdose in animals has been fatal and has been heralded by convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, abnormal respiration, cyanosis, ataxia, mydriasis, salivation, and lacrimation. The elimination half-life of sumatriptan is approximately 2.5 hours and therefore monitoring of patients after overdose with Imitrex Tablets should continue for at least 12 hours or while symptoms or signs persist. Frequent were diarrhea and gastric symptoms. In carcinogenicity studies, rats and mice were given sumatriptan by oral gavage (rats, 104 weeks) or drinking water (mice, 78 weeks).

Overdosage

The highest dose administered to rats (160 mg/kg/day, reduced from 360 mg/kg/day during week 21) was approximately 15 times the maximum recommended single human oral dose of 100 mg on a mg/m basis. Sumatriptan was not mutagenic in the presence or absence of metabolic activation when tested in 2 gene mutation assays (the Ames test and the in vitro mammalian Chinese hamster V79/HGPRT assay). Patients (N = 670) have received single oral doses of 140 to 300 mg without significant adverse effects.