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Generic Kytril Granisetron 1mg

Kytril Tablets and Kytril Oral Solution contain granisetron hydrochloride, an antinauseant and antiemetic agent. A single 2 mg dose of Kytril (granisetron hydrochloride) has been approved for the treatment of nausea and vomiting associated with chemotherapy. Until now, the recommended dosage for Kytril tablets was one 1 mg tablet administered anytime within one hour before chemotherapy and a second 1 mg tablet 12 hours after the first. Now cancer patients can take Kytril tablets either once or twice daily to prevent nausea and vomiting associated with chemotherapy. Kytril (granisetron hydrochloride) is indicated for the prevention of: nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy, including high-dose cisplatin.

Package	Price	Per Pill	Order
1mg × 60 pills	$140.00	US $ 2.33
1mg × 120 pills	$255.00	US $ 2.12

Kytril Clinical Results

Investigators evaluated the percentage of patients who achieved a complete response (no vomiting, no moderate or severe nausea and no rescue medication) and the incidence of emesis and nausea. Patients receiving a single 2 mg dose of Kytril tablets achieved a 64 percent response rate versus 69 percent for patients receiving Kytril tablets twice daily. Kytril is mainly indicated to treat and prevent nausea and vomiting associated with cancer chemotography, radiation therapy, and anesthesia used during surgery. This labeling change was based in part on results from a double-blind multicenter trial in which 697 patients were randomized to receive either a single 2 mg dose of Kytril tablets or one 1 mg Kytril tablet one hour prior to chemotherapy and another 1 mg tablet 12 hours after the first tablet was given.

Kytril Warnings

Do not take your medicine more often than directed.Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.Note: In the 2 mg once-daily regimen, two 1 mg tablets or 10 mL of Kytril Oral Solution (2 teaspoonfuls, equivalent to 2 mg of granisetron) are given up to 1 hour before chemotherapy. In the 1 mg twice-daily regimen, the first 1 mg tablet or one teaspoonful (5 mL) of Kytril Oral Solution is given up to 1 hour before chemotherapy, and the second tablet or second teaspoonful (5 mL) of Kytril Oral Solution, 12 hours after the first.

Kytril Adverse Reactions

Follow your doctor's instruction on taking Kytril medicine. Take each dose of Kytril with a full glass of water, that is 8 ounce of water. Kytril can be taken with or without food since Kytril do not any stomach upsets. Chemotherapy-Induced Nausea and Vomiting: Over 3700 patients have received Kytril Tablets in clinical trials with emetogenic cancer therapies consisting primarily of cyclophosphamide or cisplatin regimens. Kytril works by blocking the serotonin 5-HT3 receptor.

What May Interact With This Medicine?

Ketoconazole , phenobarbital.This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Kytril drug label information in our database does not contain a dedicated section on drug interactions. Also tell them if you smoke, drink alcohol, or use illegal drugs.

Overdosage

In case of overdosage, symptomatic treatment should be given. During chemotherapy that induces vomiting, mucosal enterochromaffin cells release serotonin, which stimulates 5- HT3 receptors. Serotonin receptors of the 5-HT3 type are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. This evokes vagal afferent discharge, inducing vomiting. Animal studies demonstrate that, in binding to 5-HT3 receptors, granisetron blocks serotonin stimulation and subsequent vomiting after emetogenic stimuli such as cisplatin.