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If you are experiencing any of the side effects that have been listed here, you should alert your personal physician as soon as possible. An overdose of Lasix can cause symptoms of severe dehydration. If you suspect an overdose, seek medical attention immediately. The skin of some patients may be more sensitive to the effects of sunlight while taking furosemide. Abnormalities should be corrected or the drug temporarily withdrawn. Other medications may also influence serum electrolytes. Reversible elevations of BUN may occur and are associated with dehydration, which should be avoided, particularly in patients with renal insufficiency. Lasix may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function.
WarningsSerum electrolytes (particularly potassium), CO 2, creatinine and BUN should be determined frequently during the first few months of Lasix therapy and periodically thereafter. Serum and urine electrolyte determinations are particularly important when the patient is vomiting profusely or receiving parenteral fluids. Lasix should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity. Patients receiving high doses of salicylates concomitantly with Lasix, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites. Lasix has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine. Lasix Adverse ReactionsPatients receiving both drugs should be observed closely to determine if the desired diuretic and/or antihypertensive effect of Lasix is achieved. There are no adequate and well-controlled studies in pregnant women. Lasix should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Adverse reactions are categorized below by organ system and listed by decreasing severity. In all three, the oral LD 50 exceeded 1000 mg/kg body weight, while the intravenous LD 50 ranged from 300 to 680 mg/kg. The acute intragastric toxicity in neonatal rats is 7 to 10 times that of adult rats. Lasix OverdosageFurosemide was devoid of mutagenic activity in various strains of Salmonella typhimurium when tested in the presence or absence of an in vitro metabolic activation system, and questionably positive for gene mutation in mouse lymphoma cells in the presence of rat liver S9 at the highest dose tested. Furosemide did not induce sister chromatid exchange in human cells in vitro, but other studies on chromosomal aberrations in human cells in vitro gave conflicting results. The concentration of Lasix in biological fluids associated with toxicity or death is not known. Treatment of overdosage is supportive and consists of replacement of excessive fluid and electrolyte losses. Serum electrolytes, carbon dioxide level and blood pressure should be determined frequently. The acute toxicity of Lasix has been determined in mice, rats and dogs. The principal signs and symptoms of overdose with Lasix are dehydration, blood volume reduction, hypotension, electrolyte imbalance, hypokalemia and hypochloremic alkalosis, and are extensions of its diuretic action. Adequate drainage must be assured in patients with urinary bladder outlet obstruction (such as prostatic hypertrophy). |
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