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Generic Levaquin Levofloxacin 250/500mg

Levaquin is an antibiotic in a class of drugs called fluoroquinolones. The tablets can be taken with food or on an empty stomach. However, combining either form of Levaquin with certain medications could interfere with absorption. Avoid taking the tablets or solution within 2 hours of the following: Aluminum or magnesium antacids Iron supplements Any multivitamin preparation containing zinc Didanosine chewable tablets or pediatric powder The ulcer medication Carafate Be sure to drink plenty of fluid while taking Levaquin. If you miss a dose... Take it as soon as you remember.

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Dosage And Administration

Side effects cannot be anticipated. In rare cases, Levaquin has caused convulsions and other nervous system disorders. If you develop any warning signs of a nervous reaction-ranging from restlessness and tremors to depression and hallucinations-stop taking this medication and call your doctor. Other symptoms to watch for include nerve pain, burning or tingling sensations, numbness and/or weakness, or other changes in sense perception. Levaquin may cause dizziness or light-headedness. Moderate to severe phototoxicity reactions have been observed in patients exposed to direct sunlight while receiving drugs in this class.

Why Should Levaquin Not Be Prescribed?

Remember, too, that an immediate allergic reaction is also a possibility (see "Most important fact about this drug"). A case of diarrhea during Levaquin therapy could signal development of the potentially dangerous condition known as pseudomembranous colitis, an inflammation of the bowel. Call your doctor for treatment at the first sign of a problem. Stop taking Levaquin, avoid exercise, and call your doctor if you develop pain, inflammation, or a rupture in a tendon. Quinolone antibiotics have been known to cause tendon rupture during and after therapy. The danger of this is greater when quinolones are combined with steroid medications, especially among older adults.

Precautions

Levofloxacin has not been measured in human milk. Safety and effectiveness in pediatric patients and adolescents below the age of 18 years have not been established. The possibility that Levaquin might harm a developing baby has not been ruled out. It should be used during pregnancy only if the potential benefit outweighs the possible risk. Mice, rats, dogs and monkeys exhibited the following clinical signs after receiving a single high dose of levofloxacin: ataxia, ptosis, decreased locomotor activity, dyspnea, prostration, tremors, and convulsions.

Special Warnings About Levaquin

Based upon data from ofloxacin, it can be presumed that levofloxacin will be excreted in human milk. Levaquin is not especially poisonous. Nonsteroidal anti-inflammatory drugs such as Advil, Motrin, and Naprosyn can increase the risk of a nervous reaction to Levaquin. The incidence of drug-related adverse reactions in patients during Phase 3 clinical trials conducted in North America was 6.2%. Among patients receiving levofloxacin therapy, 4.3% discontinued levofloxacin therapy due to adverse experiences. The overall incidence, type and distribution of adverse events was similar in patients receiving levofloxacin doses of 750 mg once daily compared to patients receiving doses from 250 mg once daily to 500 mg twice daily. In clinical trials, the following events were considered likely to be drug-related in patients receiving levofloxacin: nausea 1.2%, diarrhea 1.0%, vaginitis 0.6%, insomnia 0.4%, abdominal pain 0.4%, flatulence 0.3%, pruritus 0.3%, dizziness 0.3%, rash 0.3%, dyspepsia 0.2%, genital moniliasis 0.2%, moniliasis 0.2%, taste perversion 0.2%, vomiting 0.2%, injection site pain 0.2%, injection site reaction 0.2%, injection site inflammation 0.1%, constipation 0.1%, fungal infection 0.1%, genital pruritis 0.1%, headache 0.1%, nervousness 0.1%, rash erythematous 0.1%, urticaria 0.1% anorexia 0.1%, somnolence 0.1%, agitation 0.1%, rash maculopapular 0.1%, tremor 0.1%, condition aggravated 0.1%, allergic reaction 0.1%.