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Generic Levitra Vardenafil 20mg

This type of vision loss is caused by decreased blood flow to the optic nerve of the eye. It is not clear whether vardenafil is the actual cause of such vision loss. Sudden vision loss with vardenafil use has occurred most often in people with heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old. Ake each dose with a full glass of water. Avoid taking High-fat food before taking Levitra as it may cause the medicine to take more time to start working. Vardenafil is usually taken only when needed, 30 - 90 minutes before sexual activity. The medication can help achieve an erection when sexual stimulation occurs.

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Levitra Side Effects

In patients with moderate (CL cr = 30-50 ml/min) to severe (CL cr less than 30 ml/min) renal impairment, the AUC of vardenafil was 20 - 30% higher compared to that observed in a control group with normal renal function (CL cr greater than 80 ml/min) Vardenafil pharmacokinetics have not been evaluated in patients requiring renal dialysis. General: In humans, vardenafil alone in doses up to 20 mg does not prolong the bleeding time. There is no clinical evidence of any additive prolongation of the bleeding time when vardenafil is administered with aspirin.

Patient Subgroups Not Studied In Clinical Trials

Patients should be advised to contact the prescribing physician if new medications that may interact with Levitra are prescribed by another healthcare provider. Effects of Levitra on other drugs In vitro studies: Vardenafil and its metabolites had no effect on CYP1A2, 2A6, and 2E1 (Ki greater than 100 mM). Weak inhibitory effects toward other isoforms (CYP2C8, 2C9, 2C19, 2D6, 3A4) were found, but Ki values were in excess of plasma concentrations achieved following dosing.

Levitra Adverse Reactions

Erythromycin (500 mg t.i.d.) produced a 4-fold increase in vardenafil AUC and a 3-fold increase in C max when co-administered with Levitra 5 mg in healthy volunteers. It is recommended not to exceed a single 5 mg dose of Levitra in a 24-hour period when used in combination with erythromycin. Ketoconazole (200 mg once daily) produced a 10-fold increase in vardenafil AUC and a 4-fold increase in C max when co-administered with Levitra (5 mg) in healthy volunteers. A 5-mg Levitra dose should not be exceeded when used in combination with 200 mg once daily ketoconazole.

Levitra Overdosage

Vardenafil was not carcinogenic in rats and mice when administered daily for 24 months. In these studies systemic drug exposures (AUCs) for unbound (free) vardenafil and its major metabolite were approximately 400- and 170-fold for male and female rats, respectively, and 21- and 37-fold for male and female mice, respectively, the exposures observed in human males given the Maximum Recommended Human Dose (MRHD) of 20 mg. Levitra is not indicated for use in women, newborns, or children. This dose is approximately 100 fold (rat) and 29 fold (rabbit) greater than the AUC values for unbound vardenafil and its major metabolite in humans given the MRHD of 20 mg.