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Generic Lotrel 10mg + 5

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Lotrel. If you develop swelling of your face, around the lips, tongue, or throat; swelling of arms and legs; or difficulty swallowing, you should contact your doctor immediately. You may need emergency treatment. Be especially wary if you're an African American: Your chances of this type of reaction are higher. Rarely (probably less often than once in every thousand pregnancies), no alternative to ACE inhibitors will be found.

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How Should I Use This Medicine?

Lotrel is available as capsules containing amlodipine besylate equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine, with 10 mg, 20 mg or 40 mg of benazepril hydrochloride providing for the following available combinations: 2.5/10 mg, 5/10 mg, 5/20 mg, 5/40 mg, 10/20 mg and 10/40 mg. All six strengths are packaged in bottles of 100 capsules. Minimal amounts of benazepril appear in breast milk. ADULTS Your doctor will closely monitor the effects of this drug and adjust the dosage according to your blood pressure response. Lotrel is available in capsules that contain 2.5 milligrams of amlodipine and 10 milligrams of benazepril, capsules containing 5 milligrams of amlodipine and 10 or 20 milligrams of benazepril and capsules containing 10 milligrams of amlodipine and 20 milligrams of benazepril.

Rocaltrol Usage Guidelines

Like other ACE inhibitors, benazepril has been only rarely associated with hypotension in uncomplicated hypertensive patients. Symptomatic hypotension is most likely to occur in patients who have been volume and/or salt depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. Volume and/or salt depletion should be corrected before initiating therapy with Lotrel. If Lotrel is taken with certain other drugs, the effects of either could be increased, decreased, or altered.

Precautions

On a body-weight basis, this dose is over 100 times the maximum recommended human dose; on a body-surface-area basis, this dose is 18 times (rats) and 9 times (mice) the maximum recommended human dose. No mutagenic activity was detected in the Ames test in bacteria, in an in vitro test for forward mutations in cultured mammalian cells, or in a nucleus anomaly test. At doses of 50-500 mg/kg/day (38-375 times the maximum recommended human dose on a body-weight basis; 6-61 times the maximum recommended dose on a body-surface-area basis), benazepril had no adverse effect on the reproductive performance of male and female rats.

Adverse Reactions

It is not known whether amlodipine is excreted in human milk. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Amlodipine is extensively metabolized in the liver. In the elderly, clearance of amlodipine is decreased with resulting increases in peak plasma levels, elimination half-life and area-under-the-plasma-concentration curve. Human overdoses with any combination of amlodipine and benazepril have not been reported. In scattered reports of human overdoses with benazepril and other ACE inhibitors, there are no reports of death.