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Generic Loxitane Loxapine 10/25mg

Loxitane is a tricyclic antipsychotic. Although disturbances such as galactorrhea, amenorrhea, gynecomastia, and impotence have been reported, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of antipsychotic drugs. However, Loxitane and its metabolites have been shown to be transported into the milk of lactating dogs. Signs and symptoms of overdosage will depend on the amount ingested and individual patient tolerance. As would be expected from the pharmacologic actions of the drug, the clinical findings may range from mild depression of the CNS and cardiovascular systems to profound hypotension, respiratory depression, and unconsciousness.

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Loxitane Missed Dose

Store at room temperature away from sunlight and moisture. Avoid prolonged sun exposure and wear a sunscreen and protective clothing if needed. Limit alcohol intake, as it may intensify the drowsiness effect of this medication. This medication can reduce sweating making you more susceptible to heat stroke. Avoid strenuous work or exercise in hot weather. The oral concentrate form can cause redness and irritation of the skin. Be careful not to spill it on your skin or clothing. Loxitane should be used only when clearly needed during pregnancy.

Loxitane Warnings

However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses. There is no known treatment for established cases of tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn. Antipsychotic treatment itself, however, may suppress (or partially suppress) the signs and symptoms of the syndrome and thereby may possibly mask the underlying disease process.

Loxitane Precautions

Safe use of Loxitane during pregnancy or lactation has not been established; therefore, its use in pregnancy, in nursing mothers, or in women of childbearing potential requires that the benefits of treatment be weighed against the possible risks to mother and child. No embryotoxicity or teratogenicity was observed in studies in rats, rabbits, or dogs although, with the exception of one rabbit study, the highest dosage was only two times the maximum recommended human dosage and in some studies it was below this dose. The extent of the excretion of Loxitane or its metabolites in human milk is not known. The possibility of occurrence of extrapyramidal symptoms and/or convulsive seizures should be kept in mind.

Loxitane Overdosage

Renal failure following loxapine overdosage has also been reported. The treatment of overdosage is essentially symptomatic and supportive. Early gastric lavage and extended dialysis might be expected to be beneficial. Centrally-acting emetics may have little effect because of the antiemetic action of loxapine. In addition, emesis should be avoided because of the possibility of aspiration of vomitus. Avoid analeptics, such as pentylenetetrazol, which may cause convulsions.