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Generic Nimotop Nimodipine 30mg

This is a condition in which there is bleeding into the space around the brain that causes severe headaches and stiff neck. Nimotop (nimodipine) belongs to the class of pharmacological agents known as calcium channel blockers. This medicine is used to treat subarachnoid hemorrhage. Nimodipine is a calcium-channel blocker.

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Dosage And Administration

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. It is best to take this medicine at least one hour before or two hours after meals. Take your doses at regular intervals. Do not take your medicine more often than directed. Specific treatments for calcium channel blocker overdose should also be given promptly. Nimotop is given orally in the form of ivory colored, soft gelatin 30 mg capsules for subarachnoid hemorrhage.

Warnings

If you miss a dose, take it as soon as you can. Although treatment with nimodipine has not been shown to be associated with increases in intracranial pressure, close monitoring is recommended in these cases or when the water content of the brain tissue is elevated (generalized cerebral edema).

What May Interact With This Medicine?

Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Cimetidine , grapefruit juice , medicines for high blood pressure.This list may not describe all possible interactions. Blood Pressure: Nimodipine has the hemodynamic effects expected of a calcium channel blocker, although they are generally not marked. Also tell them if you smoke, drink alcohol, or use illegal drugs. However, intravenous administration of the contents of Nimotop Capsules has resulted in serious adverse consequences including death, cardiac arrest, cardiovascular collapse, hypotension, and bradycardia.

What Side Effects May I Notice From This Medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:difficulty breathing , dizziness or drowsiness , irregular or fast heartbeats (palpitations) , lightheadedness or fainting , slow heartbeat , swelling of the legs or ankles , unusual bleeding or bruising, red spots on skin , unusually weak or tired .Side The metabolism of Nimotop is decreased in patients with impaired hepatic function. Such patients should have their blood pressure and pulse rate monitored closely and should be given a lower dose. Intestinal pseudo-obstruction and ileus have been reported rarely in patients treated with nimodipine.

What Should I Watch For While Using This Medicine?

In Europe, Nimotop was observed to occasionally intensify the effect of antihypertensive compounds taken concomitantly by patients suffering from hypertension; this phenomenon was not observed in North American clinical trials. Nimodipine is metabolized via the cytochrome P450 3A4 system located both in the intestinal mucosa and in the liver. Drugs that are known to either inhibit or to induce this enzyme system may therefore alter the first pass or the clearance of nimodipine. Drugs, which are known inhibitors of the cytochrome P450 3A4 system and therefore may lead to increased plasma concentrations of nimodipine are, e.g.: macrolide antibiotics (e.g., erythromycin), anti-HIV protease inhibitors (e.g., ritonavir), azole antimycotics (e.g., ketoconazole), the antidepressants nefazodone and fluoxetine, quinupristin/dalfopristin, cimetidine, valproic acid.

Nimotop Precautions

Previous chronic administration of the antiepileptic drugs phenobarbital, phenytoin or carbamazepine markedly reduces the bioavailability of orally administered nimodipine. Therefore, the concomitant use of oral nimodipine and these antiepileptic drugs is contraindicated.

A formal interaction study investigating the potential of drug interaction between nimodipine and ketoconazole has not been performed. Azole anti-mycotics are known to inhibit the cytochrome P450 3A4 system, and various interactions have been reported for other dihydropyridine calcium antagonists.