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Check with your doctor before you stop taking Norvasc, as a slow reduction in the dose may be needed.Your doctor will prescribe Norvasc with caution if you have certain heart conditions or liver disease. You should set up a regular intake schedule, so that it will be easier to keep track of your Norvasc timetable and to prevent missing a dose. If overdose is suspected, contact your local poison control center or emergency room immediately.
Norvasc UsesCIMETIDINE: Co-administration of Norvasc with cimetidine did not alter the pharmacokinetics of Norvasc. GRAPEFRUIT JUICE: Co-administration of 240 mL of grapefruit juice with a single oral dose of amlodipine 10 mg in 20 healthy volunteers had no significant effect on the pharmacokinetics of amlodipine. MAALOX (antacid): Co-administration of the antacid Maalox with a single dose of Norvasc had no significant effect on the pharmacokinetics of Norvasc. SILDENAFIL: A single 100 mg dose of sildenafil (Viagra ) in subjects with essential hypertension had no effect on the pharmacokinetic parameters of Norvasc. How To Use Norvasc OralIf it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Storage temperature ranges differ according to different manufacturers, so consult your pharmacist for more information. Do not store in the bathroom. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Your condition can cause complications in a medical emergency. Norvasc PrecautionsATORVASTATIN: Co-administration of multiple 10 mg doses of Norvasc with 80 mg of atorvastatin resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin. Rats and mice treated with amlodipine maleate in the diet for up to two years, at concentrations calculated to provide daily dosage levels of 0.5, 1.25, and 2.5 amlodipine mg/kg/day, showed no evidence of a carcinogenic effect of the drug. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Norvasc Side EffectsNorvasc has been evaluated for safety in more than 11,000 patients in U.S. and foreign clinical trials. In general, treatment with Norvasc was well-tolerated at doses up to 10 mg daily. Most adverse reactions reported during therapy with Norvasc were of mild or moderate severity. In controlled clinical trials directly comparing Norvasc in doses up to 10 mg to placebo discontinuation of Norvasc due to adverse reactions was required in only about 1.5% of patients and was not significantly different from placebo (about 1%). |
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