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Generic Provera Medroxyprogesterone usp 10mg

If you think you will want to get pregnant shortly after you stop using birth control, Depo-Provera may not be the ideal method for you. Provera may be taken with or between meals.Do not change from one brand to another without consulting your doctor or pharmacist.If you miss a dose...Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.Storage Progestin withdrawal bleeding usually occurs within three to seven days after discontinuing therapy with Provera. The exact amount of Depo Provera to be injected can only be effectively determined by your doctor.

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What Side Effects May Occur?

If the patient is exclusively breastfeeding, the Depo Provera dose must be given at the sixth week after giving birth. When Depo Provera is used to prevent pregnancy, it should be administered at 3-month intervals to ensure total protection against pregnancy. Average follow-up in HERS II was an additional 2.7 years, for a total of 6.8 years overall. Children born to women who were taking Depo-Provera show no signs of poor health or development. Because Depo-Provera does not prevent the breasts from producing milk, it can be used by women who are breastfeeding.

Warnings

In the estrogen plus progestin Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, a population of 4,532 postmenopausal women aged 65 to 79 years was randomized to daily conjugated estrogens (CE 0.625 mg) plus medroxyprogesterone acetate (MPA 2.5 mg) or placebo. After an average follow-up of 4 years, 40 women in the CE/MPA group and 21 women in the placebo group were diagnosed with probable dementia. The relative risk of probable dementia for CE/MPA versus placebo was 2.05 (95 percent CI, 1.21-3.48). but was not statistically significant. Overdosage of estrogen plus progestin therapy may cause nausea and vomiting, breast tenderness, dizziness, abdominal pain, drowsiness/fatigue and withdrawal bleeding may occur in women.

Overdosage

An increased risk of endometrial cancer has been reported with the use of unopposed estrogen therapy in women with a uterus. The reported endometrial cancer risk among unopposed estrogen users is about 2- to 12 times greater than in nonusers, and appears dependent on duration of treatment and on estrogen dose. Most studies show no significant increased risk associated with the use of estrogens for less than 1 year. The greatest risk appears associated with prolonged use, with increased risks of 15- to 24-fold for 5 to 10 years or more.