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Generic Rebetol Ribavirin 200mg

Copegus when combined with Interferon alfa product is used treating chronic hepatitis C. It is used in patients with liver disease who have not been previously treated with Interferon alfa or those who have relapses from alfa Interferon therapy. Some MEDICINES MAY INTERACT with Ribavirin. Tell your health care provider if you are taking any other medicines, especially any of the following: Didanosine or other nucleoside reverse transcriptase inhibitors (NRTIs) (eg, lamivudine), immunosuppressants (eg, cyclosporine), or other antiretroviral medicines for HIV infection because serious side effects, including risk of infection, nerve problems (peripheral neuropathy), pancreas problems, lactic acidosis, and severe or fatal liver failure, may be increased by Ribavirin, Anticoagulants (eg, warfarin) because the effectiveness of Ribavirin may be decreased.

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200mg × 30 pills	$269.95	US $ 9.00

Indications And Usage

The drug poses a significant risk of serious harm to developing infants, even at lower doses, and it can also cause abnormalities in a man's sperm. The doctor will want to see a negative pregnancy report immediately before starting Rebetol therapy; and pregnancy tests should be done every month during therapy and for six months after it stops. Use Ribavirin as directed by your doctor. Check the label on the medicine for exact dosing instructions. Ribavirin comes with an additional patient information sheet called a Medication Guide. Read it carefully and reread it each time you get Ribavirin refilled. Ribavirin should be taken with food. Drinking extra fluids while you are taking Ribavirin is recommended. Check with your doctor for instructions.

Rebetol Overdosage

Rebetol Capsules and Oral Solution may cause birth defects and/or death of the exposed fetus. Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients. BECAUSE THE INITIAL DROP IN HEMOGLOBIN MAY BE SIGNIFICANT, IT IS ADVISED THAT HEMOGLOBIN OR HEMATOCRIT BE OBTAINED PRETREATMENT AND AT WEEK 2 AND WEEK 4 OF THERAPY, OR MORE FREQUENTLY IF CLINICALLY INDICATED. Ribavirin for inhalation has a separate package insert, which should be consulted if ribavirin inhalation therapy is being considered. Rebetol should not be initiated until a report of a negative pregnancy test has been obtained immediately prior to initiation of therapy.

Rebetol Precautions

However, this dose was less than the maximum tolerated dose, and therefore the study was not adequate to fully characterize the carcinogenic potential of ribavirin. Ribavirin demonstrated increased incidences of mutation and cell transformation in multiple genotoxicity assays. Ribavirin was active in the Balb/3T3 In Vitro Cell Transformation Assay. Based on a multiple-dose half-life (t 1/2) of ribavirin of 12 days, effective contraception must be utilized for 6 months posttherapy (e.g., 15 half-lives of clearance for ribavirin). Rat pups dosed from postnatal day 7 through 63 demonstrated a minor, dose-related decrease in overall growth at all doses, which was subsequently manifested as slight decreases in body weight, crown-rump length and bone length.

Rebetol Adverse Reactions

The primary toxicity of ribavirin is hemolytic anemia. Hemoglobin decreases among patients receiving Rebetol therapy began at Week 1, with stabilization by Week 4. In previously untreated patients treated for 48 weeks the mean maximum decrease from baseline was 3.1 g/dL in the US study and 2.9 g/dL in the International study. Increases in both bilirubin and uric acid, associated with hemolysis, were noted in clinical trials. Most were moderate biochemical changes and were reversed within 4 weeks after treatment discontinuation. Rebetol induced a decrease in hemoglobin levels in approximately two thirds of patients.