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Generic Retrovir Zidovudine 100mg

Retrovir is prescribed for adults infected with human immunodeficiency virus (HIV). HIV causes the immune system to break down so that it can no longer respond effectively to infection, leading to the fatal disease known as acquired immune deficiency syndrome (AIDS). Retrovir in combination with other antiretroviral agents has been shown to be superior to monotherapy for one or more of the following endpoints: delaying death, delaying development of AIDS, increasing CD4+ cell counts, and decreasing plasma HIV-1 RNA.

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Most Important Fact About Retrovir

Also, because Retrovir is not a cure for HIV infections or AIDS, those who are infected may continue to develop complications, including opportunistic infections that develop when the immune system falters. Do not share this medication with anyone and do not exceed your recommended dosage. Take it at even intervals every 4 hours around the clock (children every 6 hours).If you are pregnant, take the drug 5 times a day.If you miss a dose...Take it as soon as you remember. If a patient disobeys his physician (he or she does not follow the instructions that his physician has prescribed him regarding therapy with Retrovir), his treatment might not be effective enough.

Retrovir Drug Reactions

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek emergency medical treatment immediately. 2 mg/kg orally every 6 hours starting within 12 hours after birth and continuing through 6 weeks of age. Retrovir should not be administered concomitantly with COMBIVIR or TRIZIVIR. Frequent blood counts are strongly recommended in patients with advanced HIV disease who are treated with Retrovir. A majority of these cases have been in women. Obesity and prolonged exposure to antiretroviral nucleoside analogues may be risk factors. Redistribution/accumulation of body fat, including central obesity, dorsocervical fat enlargement (buffalo hump), peripheral wasting, facial wasting, breast enlargement, and "cushingoid appearance," have been observed in patients receiving antiretroviral therapy.

Zidovudine Precautions

Concomitant use of zidovudine with stavudine should be avoided since an antagonistic relationship has been demonstrated in vitro. The frequency and severity of adverse events associated with the use of Retrovir are greater in patients with more advanced infection at the time of initiation of therapy. Anemia occurred in 22% of the neonates who received Retrovir and in 12% of the neonates who received placebo. The mean difference in hemoglobin values was less than 1.0 g/dL for neonates receiving Retrovir compared to neonates receiving placebo. These involved exposures up to 50 grams. No specific symptoms or signs have been identified following acute overdosage with zidovudine apart from those listed as adverse events such as fatigue, headache, vomiting, and occasional reports of hematological disturbances.

Zidovudine Adverse Reactions

Phenytoin plasma levels have been reported to be low in some patients receiving Retrovir, while in one case a high level was documented. Acute overdoses of zidovudine have been reported in pediatric patients and adults. All patients recovered without permanent sequelae. However, in a pharmacokinetic interaction study in which 12 HIV-positive volunteers received a single 300-mg phenytoin dose alone and during steady-state zidovudine conditions (200 mg every 4 hours), no change in phenytoin kinetics was observed.