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parkinson and alzheimer / Generic Sinemet At the internet pharmacy you can buy discreetly shipped sinemet tablets and it will cost you considerably less!
A treatment with this product could also trigger some other less severe but more common side effects like mild vomiting, nausea, or decreased appetite; dry mouth, constipation, or blurred vision; muscle twitches; hand tremor; confusion, insomnia, or nightmares; darkening of your sweat, urine, or saliva; drowsiness or dizziness; anxiety or agitation; fatigue. A prolonged intake of Sinemet could also trigger some other side effects or symptoms that have not been mentioned here.
OverdosageCaution should be exercised when the following drugs are administered concomitantly with Sinemet (Carbidopa-Levodopa). Symptomatic postural hypotension has occurred when Sinemet was added to the treatment of a patient receiving antihypertensive drugs. Therefore, when therapy with Sinemet is started, dosage adjustment of the antihypertensive drug may be required. For patients receiving MAO inhibitors (Type A or B), see CONTRAINDICATIONS. Concomitant therapy with selegiline and carbidopa-levodopa may be associated with severe orthostatic hypotension not attributable to carbidopa-levodopa alone There have been rare reports of adverse reactions, including hypertension and dyskinesia, resulting from the concomitant use of tricyclic antidepressants and Sinemet. PrecautionsSinemet may cause a false-positive reaction for urinary ketone bodies when a test tape is used for determination of ketonuria. Dopamine D 2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone) and isoniazid may reduce the therapeutic effects of levodopa. In addition, the beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with Sinemet should be carefully observed for loss of therapeutic response. It has been reported from individual cases that levodopa crosses the human placental barrier, enters the fetus, and is metabolized. Adverse ReactionsIron salts may reduce the bioavailability of levodopa and carbidopa. In a two-year bioassay of Sinemet, no evidence of carcinogenicity was found in rats receiving doses of approximately two times the maximum daily human dose of carbidopa and four times the maximum daily human dose of levodopa. Pregnancy Category C. No teratogenic effects were observed in a study in mice receiving up to 20 times the maximum recommended human dose of Sinemet. There was a decrease in the number of live pups delivered by rats receiving approximately two times the maximum recommended human dose of carbidopa and approximately five times the maximum recommended human dose of levodopa during organogenesis. Hypersensitivity: angioedema, urticaria, pruritus, Henoch-Schonlein purpura, bullous lesions (including pemphigus-like reactions). Sinemet caused both visceral and skeletal malformations in rabbits at all doses and ratios of carbidopa/levodopa tested, which ranged from 10 times/5 times the maximum recommended human dose of carbidopa/levodopa to 20 times/10 times the maximum recommended human dose of carbidopa/levodopa. There are no adequate or well-controlled studies in pregnant women. Cardiovascular: cardiac irregularities, hypotension, orthostatic effects including orthostatic hypotension, hypertension, syncope, phlebitis, palpitation. Gastrointestinal: dark saliva, gastrointestinal bleeding, development of duodenal ulcer, anorexia, vomiting, diarrhea, constipation, dyspepsia, dry mouth, taste alterations. |
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