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Generic Sinemet Cr 50mg + 200

Sinemet CR is a controlled-release tablet that may be given to help relieve the muscle stiffness, tremor, and weakness caused by Parkinson's disease. It may also be given to relieve Parkinson-like symptoms caused by encephalitis (brain fever), carbon monoxide poisoning, or manganese poisoning.Sinemet If you have been taking regular Sinemet, be aware that you may need a somewhat higher dosage of Sinemet CR to get the same degree of relief. Take Sinemet CR after meals, rather than before or between meals. Swallow the tablets whole without chewing or crushing them.Sinemet CR releases its ingredients slowly over a period of 4 to 6 hours. It is important to follow a careful schedule, taking your doses at the same time every day.You should not change the prescribed dosage or add another product for Parkinson's disease without first consulting your doctor.Sinemet CR works best when there is a constant amount in the blood.

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Why Should Sinemet CR Not Be Prescribed?

Too much Sinemet CR may cause muscle twitches, inability to open the eyes, or other symptoms of levodopa overdosage. Like other medications, Sinemet CR taken in excess can have serious consequences. For patients receiving monoamine oxidase (MAO) inhibitors (Type A or B), see CONTRAINDICATIONS. Concomitant therapy with selegiline and carbidopa-levodopa may be associated with severe orthostatic hypotension not attributable to carbidopa-levodopa alone There have been rare reports of adverse reactions, including hypertension and dyskinesia, resulting from the concomitant use of tricyclic antidepressants and carbidopa-levodopa preparations.

Overdosage

Too much Sinemet CR may cause muscle twitches, inability to open the eyes, or other symptoms of levodopa overdosage. Therefore, when therapy with Sinemet Cr is started, dosage adjustment of the antihypertensive drug may be required. Dopamine D 2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone) and isoniazid may reduce the therapeutic effects of levodopa. In addition, the beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with Sinemet Cr should be carefully observed for loss of therapeutic response.

Precautions

In a two-year bioassay of SINEMET (Carbidopa-Levodopa), no evidence of carcinogenicity was found in rats receiving doses of approximately two times the maximum daily human dose of carbidopa and four times the maximum daily human dose of levodopa (equivalent to 8 Sinemet Cr tablets). SINEMET (Carbidopa-Levodopa) caused both visceral and skeletal malformations in rabbits at all doses and ratios of carbidopa/levodopa tested, which ranged from 10 times/5 times the maximum recommended human dose of carbidopa/levodopa to 20 times/10 times the maximum recommended human dose of carbidopa/levodopa.

Management of acute overdosage with Sinemet Cr is the same as with levodopa. Pyridoxine is not effective in reversing the actions of Sinemet Cr. General supportive measures should be employed, along with immediate gastric lavage. Intravenous fluids should be administered judiciously and an adequate airway maintained. Electrocardiographic monitoring should be instituted and the patient carefully observed for the development of arrhythmias; if required, appropriate antiarrhythmic therapy should be given. To date, no experience has been reported with dialysis; hence, its value in overdosage is not known. The possibility that the patient may have taken other drugs as well as Sinemet Cr should be taken into consideration.