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Stromectol is indicated for the treatment of the following infections: Strongyloidiasis of the intestinal tract. Stromectol is indicated for the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis. This indication is based on clinical studies of both comparative and open-label designs, in which 64-100% of infected patients were cured following a single 200-mcg/kg dose of ivermectin. Onchocerciasis. Infection with intestinal threadworm most often is caused when the threadworm penetrates the skin of the feet through contaminated soil or through eating contaminated food. In these patients, the following adverse experiences have also been reported: pain (including neck and back pain), red eye, conjunctival hemorrhage, dyspnea, urinary and/or fecal incontinence, difficulty in standing/walking, mental status changes, confusion, lethargy, stupor, seizures, or coma.
Stromectol PrecautionsSufferers of Stromectol over dosage must be given immediate professional medical attention. Long-term studies in animals have not been performed to evaluate the carcinogenic potential of ivermectin. Ivermectin was not genotoxic in vitro in the Ames microbial mutagenicity assay of Salmonella typhimurium strains TA1535, TA1537, TA98, and TA100 with and without rat liver enzyme activation, the Mouse Lymphoma Cell Line L5178Y (cytotoxicity and mutagenicity) assays, or the unscheduled DNA synthesis assay in human fibroblasts. Stromectol Missed DoseClinical studies of Stromectol did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In four clinical studies involving a total of 109 patients given either one or two doses of 170 to 200 mcg/kg of Stromectol, the following adverse reactions were reported as possibly, probably, or definitely related to Stromectol: Body as a Whole: asthenia/fatigue (0.9%), abdominal pain (0.9%), Gastrointestinal: anorexia (0.9%), constipation (0.9%), diarrhea (1.8%), nausea (1.8%), vomiting (0.9%), Nervous System/Psychiatric: dizziness (2.8%), somnolence (0.9%), vertigo (0.9%), tremor (0.9%), Skin: pruritus (2.8%), rash (0.9%), and urticaria (0.9%). What Should I Watch For While Using This Medicine?Stromectol is excreted in human milk in low concentrations. The following ophthalmological side effects do occur due to the disease itself but have also been reported after treatment with Stromectol: abnormal sensation in the eyes, eyelid edema, anterior uveitis, conjunctivitis, limbitis, keratitis, and chorioretinitis or choroiditis. At these doses, the treatment-related signs that were observed in these animals include ataxia, bradypnea, tremors, ptosis, decreased activity, emesis, and mydriasis. In accidental intoxication with, or significant exposure to, unknown quantities of veterinary formulations of ivermectin in humans, either by ingestion, inhalation, injection, or exposure to body surfaces, the following adverse effects have been reported most frequently: rash, edema, headache, dizziness, asthenia, nausea, vomiting, and diarrhea. Stromectol Adverse ReactionsIn comparative trials, patients treated with Stromectol experienced more abdominal distention and chest discomfort than patients treated with albendazole. In clinical trials involving 109 patients given either one or two doses of 170 to 200 mcg/kg Stromectol, the following laboratory abnormalities were seen regardless of drug relationship: elevation in ALT and/or AST (2%), decrease in leukocyte count (3%). In clinical trials, ophthalmological conditions were examined in 963 adult patients before treatment, at day 3, and months 3 and 6 after treatment with 100 to 200 mcg/kg Stromectol. Changes observed were primarily deterioration from baseline 3 days post-treatment. Most changes either returned to baseline condition or improved over baseline severity at the month 3 and 6 visits. Stromectol OverdosageNo significant lethality was observed in dogs after single oral doses of up to 10 mg/kg. Other adverse effects that have been reported include: seizure, ataxia, dyspnea, abdominal pain, paresthesia, urticaria, and contact dermatitis. In case of accidental poisoning, supportive therapy, if indicated, should include parenteral fluids and electrolytes, respiratory support (oxygen and mechanical ventilation if necessary) and pressor agents if clinically significant hypotension is present. Significant lethality was observed in mice and rats after single oral doses of 25 to 50 mg/kg and 40 to 50 mg/kg, respectively. |
