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Generic Toprol Metoprolol 25/50/100mg

Toprol XL must be taken as directed by your physician. If there is any instruction that appears unclear to you, ask your doctor, nurse, or pharmacist. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Symptoms of over dosage include: Slow heart beat , Shortness of breath , Fainting , Dizziness , Weakness , Confusion , Nausea , vomiting . Contact your doctor right away if your symptoms worsen. Check your blood pressure and pulse rate regularly. Ask your health care professional what your blood pressure and pulse rate should be, and when you should contact them.You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you.

Package	Price	Per Pill	Order
25mg × 30 pills	$30.00	US $ 1.00
25mg × 60 pills	$55.00	US $ 0.92
25mg × 90 pills	$80.00	US $ 0.89
25mg × 120 pills	$100.00	US $ 0.83
25mg × 180 pills	$135.00	US $ 0.75
25mg × 360 pills	$250.00	US $ 0.69

Package	Price	Per Pill	Order
50mg × 30 pills	$40.00	US $ 1.33
50mg × 60 pills	$75.00	US $ 1.25
50mg × 90 pills	$100.00	US $ 1.11
50mg × 120 pills	$120.00	US $ 1.00
50mg × 180 pills	$160.00	US $ 0.89
50mg × 360 pills	$300.00	US $ 0.83

Package	Price	Per Pill	Order
100mg × 30 pills	$50.00	US $ 1.67
100mg × 60 pills	$90.00	US $ 1.50
100mg × 90 pills	$125.00	US $ 1.39
100mg × 120 pills	$150.00	US $ 1.25
100mg × 180 pills	$200.00	US $ 1.11
100mg × 360 pills	$350.00	US $ 0.97

Dosage And Administration

Unless directed by your doctor, Toprol XL must not be double dosed. Alcohol may interfere with the effect of this medicine. These increases in plasma concentration would decrease the cardioselectivity of metoprolol. In 2-year studies in rats at three oral dosage levels of up to 800 mg/kg/day (41 times, on a mg/m basis, the daily dose of 200 mg for a 60-kg patient), there was no increase in the development of spontaneously occurring benign or malignant neoplasms of any type. The only histologic changes that appeared to be drug related were an increased incidence of generally mild focal accumulation of foamy macrophages in pulmonary alveoli and a slight increase in biliary hyperplasia.

What Side Effects May I Notice From This Medicine?

per day or 5 lbs. in a week) , Chest (heart) pain , Unusually cold or blue feet and hands , Skin rash . Minor side effects that are more likely to occur include: Fatigue or confusion , Headache or dizziness , Weak pulse or mildly slow heart rate , Diarrhea, constipation, gas, nausea, or vomiting , Depression , nightmares . In any of the less severe cases above, just continue use of Toprol XL and see your doctor. Patients should be advised (1) to avoid operating automobiles and machinery or engaging in other tasks requiring alertness until the patient's response to therapy with Toprol-XL has been determined; (2) to contact the physician if any difficulty in breathing occurs; (3) to inform the physician or dentist before any type of surgery that he or she is taking Toprol-XL.

Toprol Precautions

In healthy subjects with CYP2D6 extensive metabolizer phenotype, coadministration of quinidine 100 mg and immediate release metoprolol 200 mg tripled the concentration of S-metoprolol and doubled the metoprolol elimination half-life. In four patients with cardiovascular disease, coadministration of propafenone 150 mg t.i.d. with immediate release metoprolol 50 mg t.i.d. resulted in two- to five-fold increases in the steady-state concentration of metoprolol. Digitalis glycosides, in association with beta-blockers, may increase atrioventricular conduction time and may induce bradycardia. In a 21-month study in Swiss albino mice at three oral dosage levels of up to 750 mg/kg/day (18 times, on a mg/m basis, the daily dose of 200 mg for a 60-kg patient), benign lung tumors (small adenomas) occurred more frequently in female mice receiving the highest dose than in untreated control animals.

Potential Adverse Reactions

Long-term studies in animals have been conducted to evaluate the carcinogenic potential of metoprolol tartrate. There was no increase in malignant or total (benign plus malignant) lung tumors, nor in the overall incidence of tumors or malignant tumors. This 21-month study was repeated in CD-1 mice, and no statistically or biologically significant differences were observed between treated and control mice of either sex for any type of tumor. All genotoxicity tests performed on metoprolol tartrate (a dominant lethal study in mice, chromosome studies in somatic cells, a Salmonella /mammalian-microsome mutagenicity test, and a nucleus anomaly test in somatic interphase nuclei) and metoprolol succinate (a Salmonella /mammalian-microsome mutagenicity test) were negative.