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Generic Valtrex Valacyclovir 0.5/1mg

Valtrex works best if continued from the early stage of infection. It is very important to take the drug regularly for effective results. The intake of the drug shouldn't be stopped all of a sudden without consulting a doctor. It is safer to keep away from sexual play while the medication is on. If you are taking Valtrex with certain other drugs, the effect of either drug could be increased, decreased, or altered. GENITAL HERPES The usual dose for the first attack is 1 gram twice a day for 10 days.

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Overdosage

Dosage is based on the type of infection, your medical condition, and response to treatment. To treat chicken pox or shingles, start taking valacyclovir at the first symptom or after the rash first appears. To treat cold sores or genital herpes, start taking this medication at the first sign of symptoms (such as tingling/itching/burning feeling). Continue to take this medication until the full-prescribed amount is finished even if symptoms disappear. When using this drug to suppress/control outbreaks, take exactly as directed by your doctor.

Precautions

An Ames assay was negative in the absence or presence of metabolic activation. The occurrence rate of birth defects approximates that found in the general population. However, the small size of the registry is insufficient to evaluate the risk for less common defects or to permit reliable or definitive conclusions regarding the safety of acyclovir in pregnant women and their developing fetuses. Following oral administration of a 500-mg dose of Valtrex to 5 nursing mothers, peak acyclovir concentrations (C max) in breast milk ranged from 0.5 to 2.3 times (median 1.4) the corresponding maternal acyclovir serum concentrations.

Valacyclovir Adverse Reactions

There was no significant difference in the incidence of tumors between treated and control animals, nor did valacyclovir shorten the latency of tumors. Valacyclovir was tested in 5 genetic toxicity assays. Also negative were an in vitro cytogenetic study with human lymphocytes and a rat cytogenetic study. In the mouse lymphoma assay, valacyclovir was not mutagenic in the absence of metabolic activation. In the presence of metabolic activation (76% to 88% conversion to acyclovir), valacyclovir was mutagenic. The data presented below include references to the steady-state acyclovir AUC observed in humans treated with 1 gram Valtrex given orally 3 times a day to treat herpes zoster.