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Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Caution should be exercised when inhibitors of CYP3A, including Viracept, are coadministered with drugs that are metabolized by CYP3A and that prolong the QT interval. Nelfinavir is metabolized by CYP3A and CYP2C19. Coadministration of Viracept and drugs that induce CYP3A or CYP2C19 may decrease nelfinavir plasma concentrations and reduce its therapeutic effect. Coadministration of Viracept and drugs that inhibit CYP3A or CYP2C19 may increase nelfinavir plasma concentrations.
What Should I Watch For While Using This Medicine?There have been reports of increased bleeding, including spontaneous skin hematomas and hemarthrosis, in patients with hemophilia type A and B treated with protease inhibitors. Redistribution/accumulation of body fat including central obesity, dorsocervical fat enlargement (buffalo hump), peripheral wasting, facial wasting, breast enlargement, and "cushingoid appearance" have been observed in patients receiving antiretroviral therapy. Viracept PrecautionsIf you are pregnant or plan to become pregnant, tell your doctor immediately.Do Patients should be informed that Viracept Tablets are film-coated and that this film-coating is intended to make the tablets easier to swallow. The most frequent adverse event associated with Viracept is diarrhea, which can usually be controlled with non-prescription drugs, such as loperamide, which slow gastrointestinal motility. Patients should be informed that redistribution or accumulation of body fat may occur in patients receiving antiretroviral therapy and that the cause and long term health effects of these conditions are not known at this time. Viracept Adverse ReactionsThe percentage of patients with marked laboratory abnormalities in Studies 542 and 511 are presented in Table 12. Human experience of acute overdose with Viracept is limited. Viracept drug label information in our database does not contain a dedicated section on drug interactions. Administration of activated charcoal may also be used to aid removal of unabsorbed drug. There is no specific antidote for overdose with Viracept. If indicated, elimination of unabsorbed drug should be achieved by emesis or gastric lavage. |
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