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It also reduces the amount of apolipoprotein B protein that creates cholesterol in the blood. The older cholesterol-lowering drugs called "statins" reduce cholesterol by interfering with its production in the body. For people at lower risk, the cut-off is 160. Brand name for ezetimibe, Zetia belongs to antihyperlipidemic category of drugs. Zetia is best effective in lowering the amount of absorbable amount of cholesterol in body. This drug amazingly reduces the amount of total cholesterol and LDL (bad) cholesterol. The power of Zetia doesn't stop here. Zetia is the physician's first choice in bringing down cholesterol and tri-glyceride level in blood.
Indications And UsageIt's important to remember that drug therapy is a supplement to-not a substitute for-these other measures. These changes include following a diet low in fat and cholesterol and high in fiber, shedding excess weight, and getting more exercise. Monotherapy Zetia, administered alone, is indicated as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, and Apo B in patients with primary (heterozygous familial and non-familial) hypercholesterolemia. Combination therapy with HMG-CoA reductase inhibitors Zetia, administered in combination with an HMG-CoA reductase inhibitor, is indicated as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, and Apo B in patients with primary (heterozygous familial and non-familial) hypercholesterolemia. Homozygous Familial Hypercholesterolemia (HoFH) The combination of Zetia and atorvastatin or simvastatin, is indicated for the reduction of elevated total-C and LDL-C levels in patients with HoFH, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable. How Should You Take Zetia?You can take Zetia with or without food. If the doctor has also prescribed a statin drug, you can take Zetia at the same time. If you are also taking colestipol, cholestyramine, or colesevelam, take Zetia at least 2 hours before or 4 hours after taking the other medication.If you miss a dose...Take the forgotten dose as soon as you remember. The patient should be placed on a standard cholesterol-lowering diet before receiving Zetia and should continue on this diet during treatment with Zetia. The recommended dose of Zetia is 10 mg once daily. Zetia can be administered with or without food. Stop taking this drug instantly if you experience breathing trouble, closed throat, swollen lips, tongue, or face and take required medical aid from your doctor. ZETIA OverdoseSide effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Clinical studies of Zetia (administered alone or with an HMG-CoA reductase inhibitor) demonstrated that Zetia was generally well tolerated. The overall incidence of adverse events reported with Zetia was similar to that reported with placebo, and the discontinuation rate due to adverse events was also similar for Zetia and placebo. Only your doctor can determine if it is safe to continue using Zetia.Side effects may include:Abdominal pain, back pain, diarrhea, joint pain, sinusitisOther side effects that occur when Zetia is taken with a statin drug include chest pain, dizziness, headache, muscle pain, and upper respiratory infection.Certain Why Should Zetia Not Be Prescribed?If Zetia causes an allergic reaction, you'll be unable to use it. Your physician is the best person to provide you with the right usage guidelines. Regularity and punctuality are the keywords. If Zetia causes an allergic reaction, you'll be unable to use it. If you are on bile acid sequestrant such as Cholestyramine (Locholest, Prevalite, Questran), colestipol (Colestid), or colesevelam (Welchol), take Zetia 2 hours before or 4 hours after taking the acid sequestrant. Special Warnings About ZetiaIn clinical studies, administration of ezetimibe, 50 mg/day to 15 healthy subjects for up to 14 days, or 40 mg/day to 18 patients with primary hypercholesterolemia for up to 56 days, was generally well tolerated. A few cases of overdosage with Zetia have been reported; most have not been associated with adverse experiences. Reported adverse experiences have not been serious. Special Information If You Are Pregnant Or BreastfeedingIf you are pregnant or planning to become pregnant, check with your doctor immediately. Zetia should be taken during pregnancy only if its benefits outweigh the potential risk to the baby. It's not known whether Zetia makes its way into breast milk. If you are pregnant or planning to become pregnant, check with your doctor immediately.Statin drugs pose a definite risk to the baby, so you should never add a statin drug to Zetia therapy during pregnancy.It's Zetia should be taken during pregnancy only if its benefits outweigh the potential risk to the baby. How To Use Zetia OralUse this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day. If you have any questions regarding the information, consult your doctor or pharmacist. Take this medication by mouth usually once daily with or without food. If you are also taking a bile acid sequestrant (e.g., cholestyramine, colestipol), take ezetimibe at least 2 hours before or at least 4 hours after the bile acid sequestrant. Zetia NotesDo not share this medication with others. Laboratory and/or medical tests (e.g., cholesterol levels) should be performed periodically to monitor your progress. For best results, this medication should be used along with exercise and a low cholesterol/low fat diet. When ezetimibe is given with a statin agent, liver function tests should be performed to monitor for side effects. Consult your doctor for more details. Zetia StorageDo not store in the bathroom. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage from 59-86 degrees F (15-30 degrees C) is permitted. Zetia Side EffectsIf any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Dizziness, headache, diarrhea, back pain may occur. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. Many people using this medication do not have serious side effects. Tell your doctor immediately if you experience the following: muscle pain/tenderness/weakness (especially with fever or unusual tiredness) A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash itching/swelling (especially of the face/tongue/throat) dizziness trouble breathing This is not a complete list of possible side effects. Zetia InteractionsDo not start, stop, or change the dosage of any medicine before checking with them first. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: cyclosporine fibrates (e.g., fenofibrate, gemfibrozil) This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. |
