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Generic Zithromax Azithromycin 250/500mg

Additionally, Zithromax-rifabutin combination therapy was to be more effective than rifabutin as monotherapy. Antimicrobial agents used in high doses for short periods of time to treat non-gonococcal urethritis may mask or delay the symptoms of incubating gonorrhea or syphilis. All patients with sexually-transmitted urethritis or cervicitis should have a serologic test for syphilis and appropriate cultures for gonorrhea performed at the time of diagnosis. Appropriate antimicrobial therapy and follow-up tests for these diseases should be initiated if infection is confirmed.

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Zithromax Additional Information

Do not take Zithromax with antacids containing aluminum or magnesium. If Zithromax is taken with certain other drugs, the effects of either could be increased, decreased, or altered. This is followed by 250 milligrams once daily for the next 4 days. These patients required prolonged periods of observation and symptomatic treatment. The relationship of these episodes to the long tissue half-life of azithromycin and subsequent prolonged exposure to antigen is unknown at present. Due to the limited data in subjects with GFRless than 10 mL/min, caution should be exercised when prescribing azithromycin in these patients.

Precautions

With regard to the MAC prophylaxis dose of 1200 mg weekly, on a mg/m/day basis, the doses in rats and mice are approximately 2 and 1 times the human dose, respectively. No evidence of impaired fertility or harm to the fetus due to azithromycin was found. Two (2.8%) children prematurely discontinued treatment due to side effects: one due to back pain and one due to abdominal pain, hot and cold flushes, dizziness, headache, and numbness. A third child discontinued due to a laboratory abnormality (eosinophilia). Dosage adjustment does not appear to be necessary for older patients with normal renal and hepatic function receiving treatment with this dosage regimen.

Zithromax Adverse Reactions

In controlled clinical studies, azithromycin has been administered to pediatric patients ranging in age from 6 months to 12 years. The mean duration of therapy was 242 days (range 3 - 2004 days) at doses of less than 1 to 52 mg/kg/day (mean 12 mg/kg/day). Adverse events were similar to those observed in the adult population, most of which involved the gastrointestinal tract. Treatment related reversible hearing impairment in children was observed in 4 subjects (5.6%). Pharmacokinetic parameters in older volunteers (65 - 85 years old) were similar to those in younger volunteers (18 - 40 years old) for the 5-day therapeutic regimen.

Azithromycin Drug Interactions

No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. The nature of side effects seen with the 600 mg daily dosing regimen for the treatment of Mycobacterium avium complex infection in severely immunocompromised HIV-infected patients were similar to those seen with short term dosing regimens.

Five percent of patients experienced reversible hearing impairment in the pivotal clinical trial for the treatment of disseminated MAC in patients with AIDS. Hearing impairment has been reported with macrolide antibiotics, especially at higher doses. Other treatment related side effects occurring in greater than 5% of subjects and seen at any time during a median of 87.5 days of therapy include: abdominal pain (14%), nausea (14%), vomiting (13%), diarrhea (12%), flatulence (5%), headache (5%) and abnormal vision (5%).

There have been rare reports of QT prolongation and torsades de pointes. Gastrointestinal: Anorexia, constipation, dyspepsia, flatulence, vomiting/diarrhea rarely resulting in dehydration, pseudomembranous colitis, pancreatitis, oral candidiasis and rare reports of tongue discoloration. General: Asthenia, paresthesia, fatigue, malaise and anaphylaxis (rarely fatal). Genitourinary: Interstitial nephritis and acute renal failure, vaginitis. Hematopoietic: Thrombocytopenia. Liver/Biliary: Abnormal liver function including hepatitis and cholestatic jaundice, as well as rare cases of hepatic necrosis and hepatic failure, some of which have resulted in death.