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Generic Zocor Simvastatin 20mg

Zocor tends to enhance the effects of the blood-thinning drug Coumadin and the heart medication Lanoxin. Combining it with the following drugs increases the chance of muscle damage:AmiodaroneClarithromycinClofibrateCyclosporineErythromycinFenofibrateGemfibrozilItraconazoleKetoconazoleNefazodoneNicotinic acid or niacinProtease inhibitors (used in the treatment of HIV)VerapamilIf you are taking Zocor with any of these drugs (or with large quantities of grapefruit juice) alert your doctor immediately at the first sign of muscle pain or weakness. Do not take Simvastatin with any of the following: amprenavir, atazanavir, clarithromycin, delavirdine, erythromycin, grapefruit juice, indinavir, itraconazole, ketoconazole, lopinavir; ritonavir, mibefradil, nefazodone, nelfinavir, ritonavir, saquinavir, went yeast.

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Zocor Adverse Reactions

In 4S involving 4,444 patients treated with 20-40 mg/day of Zocor (n=2,221) or placebo (n=2,223), the safety and tolerability profiles were comparable between groups over the median 5.4 years of the study. Gastrointestinal: pancreatitis, hepatitis, including chronic active hepatitis, cholestatic jaundice, fatty change in liver, and, rarely, cirrhosis, fulminant hepatic necrosis, hepatic failure, and hepatoma; anorexia, vomiting. Skin: alopecia, pruritus. A variety of skin changes (e.g., nodules, discoloration, dryness of skin/mucous membranes, changes to hair/nails) have been reported. Reproductive: gynecomastia, loss of libido, erectile dysfunction. Marked persistent increases of serum transaminases have been noted About 5% of patients had elevations of CK levels of 3 or more times the normal value on one or more occasions.

Overdosage

Hypersensitivity Reactions: An apparent hypersensitivity syndrome has been reported rarely which has included one or more of the following features: anaphylaxis, angioedema, lupus erythematous-like syndrome, polymyalgia rheumatica, dermatomyositis, vasculitis, purpura, thrombocytopenia, leukopenia, hemolytic anemia, positive ANA, ESR increase, eosinophilia, arthritis, arthralgia, urticaria, asthenia, photosensitivity, fever, chills, flushing, malaise, dyspnea, toxic epidermal necrolysis, erythema multiforme, including Stevens-Johnson syndrome. Eye: progression of cataracts (lens opacities), ophthalmoplegia. In controlled clinical studies in which simvastatin was administered concomitantly with cholestyramine, no adverse reactions peculiar to this concomitant treatment were observed.

No specific diagnostic signs were observed in rodents. The adverse reactions that occurred were limited to those reported previously with simvastatin or cholestyramine. At these doses the only signs seen in dogs were emesis and mucoid stools. A few cases of overdosage with Zocor have been reported; the maximum dose taken was 3.6 g. All patients recovered without sequelae. Until further experience is obtained, no specific treatment of overdosage with Zocor can be recommended.