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Generic Zoloft Sertraline 50/100mg

Zoloft (sertraline hydrochloride) is associated with a mean decrease in serum uric acid of approximately 7%. Exclusions from this trial included, among others, patients with uncontrolled hypertension, need for cardiac surgery, history of CABG within 3 months of index event, severe or symptomatic bradycardia, non-atherosclerotic cause of angina, clinically significant renal impairment (creatinine greater than 2.5 mg/dl), and clinically significant hepatic dysfunction.

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Zoloft treatment

Zoloft treatment initiated during the acute phase of recovery (within 30 days post-MI or post-hospitalization for unstable angina) was indistinguishable from placebo in this study on the following week 16 treatment endpoints: left ventricular ejection fraction, total cardiovascular events (angina, chest pain, edema, palpitations, syncope, postural dizziness, CHF, MI, tachycardia, bradycardia, and changes in BP), and major cardiovascular events involving death or requiring hospitalization (for MI, CHF, stroke, or angina).

Zoloft Drug Interactions

The normalization of prothrombin time for the Zoloft group was delayed compared to the placebo group. In a study assessing disposition of Zoloft (100 mg) on the second of 8 days of cimetidine administration (800 mg daily), there were significant increases in Zoloft mean AUC (50%), Cmax (24%) and half-life (26%) compared to the placebo group. There was a 23% increase in Tmax for desmethyldiazepam in the Zoloft group compared to a 20% decrease in the placebo group (pless than 0.03). The clinical significance of these changes is unknown. In a placebo-controlled trial in normal volunteers, the administration of two doses of Zoloft did not significantly alter steady-state lithium levels or the renal clearance of lithium.

Zoloft Recommendations

At this time, it is recommended that plasma lithium levels be monitored following initiation of Zoloft therapy with appropriate adjustments to the lithium dose. In a controlled study of a single dose (2 mg) of pimozide, 200 mg sertraline (q.d.) co-administration to steady state was associated with a mean increase in pimozide AUC and Cmax of about 40%, but was not associated with any changes in EKG. Since the highest recommended pimozide dose (10 mg) has not been evaluated in combination with sertraline, the effect on QT interval and PK parameters at doses higher than 2 mg at this time are not known.