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IT IS NOT RECOMMENDED FOR THE TREATMENT OF ASYMPTOMATIC HYPERURICEMIA. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Check the label on the medicine for exact dosing instructions. Take Allopurinol by mouth after meals to decrease stomach upset. Allopurinol may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Allopurinol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. You may experience an increase in gout attacks for several months after you begin taking Allopurinol. These attacks will become shorter and less severe after several months of therapy.A kidney problem may turn a normal dose of Zyloprim into an overdose.

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Dosage And Administration

Only your doctor can determine if it is safe for you to continue taking Zyloprim. All medicines may cause side effects, but many people have no, or minor, side effects. If Zyloprim is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Also tell your doctor if you are taking Thiazide diuretics such as hydrochlorothiazide (Hydrodiuril, Hygroton, HCTZ), chlorothiazide (Diuril, others), chlorthalidone (Thalitone, others), or indapamide (Lozol). Diuretics may increase the amount of Zyloprim in the blood. The average dose is 200 to 300 milligrams per day for mild gout and 400 to 600 milligrams daily for moderate to severe gout.

How To Use Allopurinol :

In some people, a Zyloprim-induced rash may lead to a serious skin disease, generalized inflammation of a blood or lymph vessel, irreversible liver damage, or even death.You may experience acute attacks of gout more often in the early stages of Zyloprim therapy, even when normal uric acid levels have been attained. If you have a kidney disease, or a condition such as diabetes or high blood pressure that may affect your kidneys, your doctor should prescribe Zyloprim cautiously and order periodic blood and urine tests to assess your kidney function.Because The effects of Zyloprim during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, notify your doctor immediately.

Zyloprim Overdose

Zyloprim should be taken during pregnancy only if it is clearly needed. Your doctor may increase your dose by 100 milligrams per day at 1-week intervals until desired results are attained. The most you should take in a day is 800 milligrams. Although no specific information is available regarding Zyloprim overdosage, any medication taken in excess can have serious consequences. Although no specific information is available regarding Zyloprim overdosage, any medication taken in excess can have serious consequences. The concomitant administration of uricosuric agents and Zyloprim has been associated with a decrease in the excretion of oxypurines (hypoxanthine and xanthine) and an increase in urinary uric acid excretion compared with that observed with Zyloprim alone.

Special Warnings About Zyloprim

Drug Interactions: In patients receiving PURINETHOL (mercaptopurine) or IMURAN (azathioprine), the concomitant administration of 300 to 600 mg of Zyloprim per day will require a reduction in dose to approximately one third to one fourth of the usual dose of mercaptopurine or azathioprine. Subsequent adjustment of doses of mercaptopurine or azathioprine should be made on the basis of therapeutic response and the appearance of toxic effects It has been reported that Zyloprim prolongs the half-life of the anticoagulant, dicumarol.