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Generic Zyprexa
Olanzapine 2.5/5/7.5/10/15/20mg
Zyprexa helps manage symptoms of schizophrenia, the manic phase of bipolar disorder, and other psychotic disorders. In clinical trials, Zyprexa was superior to placebo in treating the symptoms of schizophrenia. The efficacy of Zyprexa in the management of the symptoms of psychotic disorders was established in two six-week placebo controlled trials of schizophrenic inpatients. Subjects were assessed using several test instruments, including the Brief Psychiatric Rating Scale (BPRS), an 18-item inventory of symptoms traditionally used to evaluate the effects of drug treatment in psychosis. The BPRS score was extracted from the Positive and Negative Syndrome scale (PANSS), a 30-item rating instrument that evaluates each symptom item on a scale of 1 (absent) to 7 (extreme).
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Zyprexa Side Effects
To use Zyprexa Zydis, open the sachet, peel back the foil on the blister pack, remove the tablet, and place the entire tablet in the mouth. Do not push the tablet through the foil. The medication can be taken with or without water; the saliva in your mouth will cause the tablet to dissolve.If you miss a dose...Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Schizophrenia is a clinical syndrome marked by the presence of positive psychotic symptoms, such as delusions and hallucinations, and negative symptoms, such as apathy, diminished emotions, and low motivation. People with schizophrenia can have difficulty distinguishing fantasy from reality, thinking clearly, and managing emotions.
Recommended Dosage For Zyprexa
The administration of activated charcoal (1 g) reduced the Cmax and AUC of oral olanzapine by about 60%. As peak olanzapine levels are not typically obtained until about 6 hours after dosing, charcoal may be a useful treatment for olanzapine overdose. -- Single doses of cimetidine (800 mg) or aluminum- and magnesium-containing antacids did not affect the oral bioavailability of olanzapine. -- Carbamazepine therapy (200 mg bid) causes an approximately 50% increase in the clearance of olanzapine. This increase is likely due to the fact that carbamazepine is a potent inducer of CYP1A2 activity. Higher daily doses of carbamazepine may cause an even greater increase in olanzapine clearance.
Olanzapine Adverse Reactions
This drug may also cause significant weight gain and a rise in your blood cholesterol (or triglyceride) levels. In the limited number of patients who were evaluated in hospitals, including the patient taking 300 mg, there were no observations indicating an adverse change in laboratory analytes or ECG. -- Overall, there was no difference in the incidence of discontinuation due to adverse events (0.4% for intramuscular olanzapine for injection vs 0% for placebo). Adverse Events Associated with Discontinuation of Treatment in Short-Term Combination Trials -- In a study of patients who were already tolerating either lithium or valproate as monotherapy, discontinuation rates due to adverse events were 11% for the combination of oral olanzapine with lithium or valproate compared to 2% for patients who remained on lithium or valproate monotherapy.
Zyprexa Interactions
Do not start, stop, or change the dosage of any medicine before checking with them first. The following medication should not be used with olanzapine because a very serious interaction may occur: sibutramine If you are currently using the medication listed above, tell your doctor or pharmacist before starting olanzapine. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: carbamazepine fluvoxamine drugs for high blood pressure omeprazole drugs for Parkinson's disease rifampin Report drugs that cause drowsiness such as medicine for sleep (e.g., sedatives), tranquilizers, anti-anxiety drugs (e.g., diazepam), narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), anti-seizure drugs (e.g., phenytoin), muscle relaxants, antihistamines that cause drowsiness (e.g., diphenhydramine).
