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Community-acquired pneumonia caused by Streptococcus pneumoniae (including multi-drug resistant strains [MDRSP]), including cases with concurrent bacteremia, or Staphylococcus aureus (methicillin-susceptible strains only). To reduce the development of drug-resistant bacteria and maintain the effectiveness of Zyvox and other antibacterial drugs, Zyvox should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Do not stop taking the medicine when you start to feel better. Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible.
Indications And UsageIt is caused by a buildup of lactic acid in the blood. If leaks are detected, discard the solution, as sterility may be impaired. Zyvox I.V. Injection should be administered by intravenous infusion over a period of 30 to 120 minutes. Do not use this intravenous infusion bag in series connections. Additives should not be introduced into this solution. In cases of optic neuropathy that progressed to loss of vision, patients were treated for extended periods beyond the maximum recommended duration. Visual blurring has been reported in some patients treated with Zyvox for less than 28 days. Dosage And AdministrationDiscontinuation of therapy with linezolid should be considered in patients who develop or have worsening myelosuppression. In reported cases, patients experienced repeated episodes of nausea and vomiting. Little is known about the effects of a Zyvox overdose. Large quantities of foods or beverages with high tyramine content should be avoided while taking Zyvox. Quantities of tyramine consumed should be less than 100 mg per meal. Foods high in tyramine content include those that may have undergone protein changes by aging, fermentation, pickling, or smoking to improve flavor, such as aged cheeses (0 to 15 mg tyramine per ounce); fermented or air-dried meats (0.1 to 8 mg tyramine per ounce); sauerkraut (8 mg tyramine per 8 ounces); soy sauce (5 mg tyramine per 1 teaspoon); tap beers (4 mg tyramine per 12 ounces); red wines (0 to 6 mg tyramine per 8 ounces). Special Zyvox Dosage AdjustmentIf Zyvox is to be given concomitantly with another drug, each drug should be given separately in accordance with the recommended dosage and route of administration for each product. 5% Dextrose Injection, USP 0.9% Sodium Chloride Injection, USP Lactated Ringer's Injection, USP Keep the infusion bags in the overwrap until ready to use. Store at room temperature. Protect from freezing. Peripheral and optic neuropathy have been reported in patients treated with Zyvox, primarily those patients treated for longer than the maximum recommended duration of 28 days. Zyvox PrecautionsThey should inform their physician if they have a history of hypertension. The tyramine content of any protein-rich food may be increased if stored for long periods or improperly refrigerated. They should inform their physician if taking medications containing pseudoephedrine HCl or phenylpropanolamine HCl, such as cold remedies and decongestants. They should inform their physician if taking serotonin re-uptake inhibitors or other antidepressants. Phenylketonurics: Each 5 mL of the 100 mg/5 mL Zyvox for Oral Suspension contains 20 mg phenylalanine. Adrenergic Agents: Some individuals receiving Zyvox may experience a reversible enhancement of the pressor response to indirect-acting sympathomimetic agents, vasopressor or dopaminergic agents. |
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